Actively Recruiting
Spinal Cord Injury Neuroprotection With Glyburide
Led by Francis Farhadi · Updated on 2026-02-13
12
Participants Needed
1
Research Sites
303 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To assess the safety and efficacy of using oral Glyburide (Diabeta) as a neuroprotective agent in patients with acute cervical or thoracic traumatic spinal cord injury.
CONDITIONS
Official Title
Spinal Cord Injury Neuroprotection With Glyburide
Who Can Participate
Eligibility Criteria
You may qualify if you...
- No life threatening injuries resulting from the traumatic accident
- No evidence of sepsis
- Acute cervical or thoracic spinal cord injury with ASIA Impairment Scale Grade A, B, or C on admission
- Non-penetrating spinal cord injury at neurologic level from C2 to C8 or T1 to T12
You will not qualify if you...
- Unconsciousness or mental impairment preventing neurological assessment within 8 hours
- Acute spinal cord injury with ASIA Impairment Scale grade D or E
- Currently involved in another non-observational spinal cord injury research study or receiving another investigational drug
- History of hypersensitivity to sulfonylureas, especially glyburide, or its components
- Any condition likely to cause death within 12 months
- Severe renal disorder or baseline eGFR less than 30 mL/min/1.73 m2
- Known severe liver disease or elevated liver enzymes (ALT > 3 times upper limit) or bilirubin
- Blood glucose less than 55 mg/dL at enrollment or prior to drug administration, or history of significant hypoglycemia
- Acute ST elevation myocardial infarction, acute heart failure, QTc > 520 ms, history of cardiac arrest, or recent coronary events within 3 months
- Known G6PD enzyme deficiency
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Kentucky
Lexington, Kentucky, United States, 40536
Actively Recruiting
Research Team
H
H. Francis Farhadi, MD, PhD
CONTACT
H
Harshit Arora, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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