Actively Recruiting
Spinal Cord Stimulation and Training
Led by Washington University School of Medicine · Updated on 2026-04-02
120
Participants Needed
1
Research Sites
210 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will help the investigators better understand the changes in short-term excitability and long-term plasticity of corticospinal, reticulospinal and spinal neural circuits and how the changes impact the improvements of spinal cord stimulation (SCS) mediated motor function.
CONDITIONS
Official Title
Spinal Cord Stimulation and Training
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 16 and 65 years old
- Healthy people with no major comorbidities of any organ system
- Age between 16-65 years old
- Traumatic spinal cord injury at C4-T9 level, incomplete (ASIA C or D)
- At least 1 year post injury
- Stable medical condition
- Difficulty independently performing leg movements in routine activities
- Able to follow simple commands
- Able to speak and respond to questions
You will not qualify if you...
- Younger than 16 or older than 65 years old
- Not able or willing to provide consent
- Any acute or chronic pain condition
- Any acute or chronic disease of a major organ system
- Use of analgesics within 24 hours prior to study appointment
- Use of caffeine within 3 hours of study appointment
- Presence of tremors, spasms, or other significant involuntary movements
- Cause of spinal cord injury other than trauma
- Concomitant neurologic diseases such as traumatic brain injury, multiple sclerosis, stroke, or peripheral neuropathy
- History of significant medical illness like cardiovascular disease, uncontrolled diabetes, uncontrolled hypertension, osteoporosis, cancer, chronic obstructive pulmonary disease, severe asthma requiring hospitalization, renal insufficiency needing dialysis, autonomic dysreflexia
- Severe joint contractures restricting lower limb movements
- Unhealed fracture, contracture, pressure sore, urinary tract infection, or other uncontrolled infections
- Depression, anxiety, cognitive impairment, or visuospatial orientation deficit
- Sitting tolerance less than 1 hour
- Severe hearing or visual deficiency
- Missing more than 3 appointments without notification
- Unable to comply with study procedures
- Botulinum toxin injection in lower extremity muscles in prior six months
- Any passive implants below T9
- Any implanted stimulator in the body like pacemaker or vagus nerve stimulator
- History of alcoholism or drug abuse
- Pregnancy or possible pregnancy
- Having an Intrathecal Baclofen Therapy Pump
- History of epilepsy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Washington University
St Louis, Missouri, United States, 63130
Actively Recruiting
Research Team
I
Ismael Seanez, PHD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
6
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here