Actively Recruiting
SPIROMICS Study of Early COPD Progression (SOURCE)
Led by University of Massachusetts, Worcester · Updated on 2025-05-29
1000
Participants Needed
14
Research Sites
238 weeks
Total Duration
On this page
Sponsors
U
University of Massachusetts, Worcester
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is an observational study of 1000 participants to further define the nature of early chronic obstructive pulmonary disease (COPD) in younger, at-risk individuals. The study has three main goals: * To use CT scan imaging to identify which smokers will develop COPD. * To identify biomarkers predictive of smokers that will develop COPD. * To determine if sputum (phlegm) can be analyzed to predict which smokers will develop COPD. Procedures (methods): All participants will undergo study related questionnaires assessing medical history, smoke exposure and use, medication use, social and behavioral health, pulmonary symptoms, food frequency, and will provide nasal swab, blood, stool, and urine samples, pulmonary function testing to determine function, sputum induction to provide a sputum sample for airway biospecimen analysis, and CT imaging of the lungs.
CONDITIONS
Official Title
SPIROMICS Study of Early COPD Progression (SOURCE)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ages 30 to 55 years
- Healthy controls with no significant smoking history (<100 cigarettes lifetime), normal lung function, and low airway symptom scores
- Participants with ≥10 pack-year smoking history categorized as GOLD 0, PRISm, or GOLD 1-2 based on lung function
- Willingness to provide samples and undergo lung function testing and CT imaging
- Some healthy controls willing to participate in a bronchoscopy sub-study
You will not qualify if you...
- Severe asthma requiring high-level treatment or frequent healthcare visits/hospitalization in past 12 months
- Participation in a blinded therapeutic clinical trial
- Current pregnancy or planning pregnancy during the study
- Cognitive dysfunction preventing study participation
- BMI over 35 kg/m2
- Presence of lung diseases other than COPD or significant comorbid conditions causing respiratory symptoms
- Illness expected to cause death within 3 years
- Implanted metal devices or prostheses above the waist affecting CT imaging
- History of thoracic radiation or lung surgery
- Known HIV/AIDS infection
- Current illicit substance abuse (excluding marijuana)
- History or current use of IV Ritalin or heroin
- History of illegal IV drug use within the last 10 years or more than 5 instances ever
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 14 locations
1
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35205
Actively Recruiting
2
Mayo Clinic Arizona
Scottsdale, Arizona, United States, 85259
Actively Recruiting
3
University of California Los Angeles
Los Angeles, California, United States, 90095
Actively Recruiting
4
University of California, San Francisco
San Francisco, California, United States, 94143
Actively Recruiting
5
National Jewish Health
Denver, Colorado, United States, 80206
Actively Recruiting
6
University of Illinois Chicago
Chicago, Illinois, United States, 60608
Actively Recruiting
7
University of Iowa
Iowa City, Iowa, United States, 52242
Actively Recruiting
8
Johns Hopkins Bayview Medical Center
Baltimore, Maryland, United States, 21224
Actively Recruiting
9
University of Michigan
Ann Arbor, Michigan, United States, 48130
Actively Recruiting
10
Columbia University
New York, New York, United States, 10032
Actively Recruiting
11
Weill Cornell Medical Center
New York, New York, United States, 10065
Actively Recruiting
12
Wake Forest
Winston-Salem, North Carolina, United States, 27104
Actively Recruiting
13
Temple University
Philadelphia, Pennsylvania, United States, 10140
Actively Recruiting
14
University of Utah
Salt Lake City, Utah, United States, 84108
Actively Recruiting
Research Team
L
Lori A Bateman, MS
CONTACT
D
David Couper, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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