Comparing Pressure Support Ventilation and T-Piece Methods for Breathing Trials Before Removing Breathing Tubes in Overweight and Obese Adults

What this Trial Is About

This research aims to evaluate which spontaneous breathing trial method better prepares overweight and obese adult ICU patients for extubation, the removal of the breathing tube. The study focuses on adults with a body mass index BMI of 25 or higher who have been on invasive mechanical ventilation for more than 24 hours. The goal is to determine which method leads to a higher rate of successful extubation, defined as not needing reintubation within 72 hours after extubation. Participants will be randomly assigned to one of two groups before extubation. One group will receive a spontaneous breathing trial using low-level pressure support ventilation PSV for one hour, while the other group will receive a spontaneous breathing trial using a T-piece with oxygen for one hour. After the trial, doctors will decide if the patient is ready for extubation. During the study, patients will be monitored for vital signs and respiratory stability. Researchers will track whether extubation is successful within 72 hours, which is the main outcome measure. Participants must meet specific clinical criteria before the trial and provide informed consent. The study is sponsored by Taipei Medical University Hospital and does not include additional extension or long-term follow-up periods.

Spontaneous Breathing Trials Using Pressure Support or T-Piece in Overweight and Obese Patients