Actively Recruiting
Sporadic Degenerative Ataxia With Adult Onset: Natural History Study
Led by Ataxia Study Group · Updated on 2017-06-29
300
Participants Needed
14
Research Sites
1078 weeks
Total Duration
On this page
Sponsors
A
Ataxia Study Group
Lead Sponsor
G
German Center for Neurodegenerative Diseases (DZNE)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The key goals of SPORTAX-NHS is to compare the phenotype of multiple system atrophy of cerebellar type (MSA-C) and sporadic adult onset ataxia of unknown aetiology (SAOA) and to determine the rate of disease progression in both groups including determination of the factors that predict the development of MSA-C vs. SAOA, and at which time after onset of ataxia, a reliable distinction between both disorders is possible. The planned study will also allow to collect blood samples and other biomaterials from patients with sporadic ataxia, which will be useful for future genetic and biomarker studies.
CONDITIONS
Official Title
Sporadic Degenerative Ataxia With Adult Onset: Natural History Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Progressive ataxia
- Disease onset after the age of 40 years
- Informative and negative family history (no similar disorders in first- and second-degree relatives; parents older than 50 years, or, if not alive, age at death of more than 50 years, no consanguinity of parents)
You will not qualify if you...
- No established acquired cause of ataxia
- No onset of ataxia in association with stroke, encephalitis, sepsis, hyperthermia or heat stroke
- No chronic diarrhea
- No unexplained visual loss
- No alcohol abuse
- No chronic intake of anticonvulsant drugs
- No other toxic causes
- No malignancies
- No rapid progression (development of severe ataxia in less than 12 weeks)
- No insulin-dependent diabetes mellitus
- No evidence of multiple sclerosis, ischemia, hemorrhage or tumor of the posterior fossa
- Absence of signal abnormalities on T2/FLAIR-images except abnormalities compatible with MSA
- Negative molecular genetic testing for FRDA (only required if there is no cerebellar atrophy on MRI), SCA1, SCA2, SCA3, SCA6, FMR1 premutation (only required if prominent tremor, cognitive impairment and signal abnormality on T2/FLAIR images in the middle cerebellar peduncle)
- Antineuronal antibodies negative (only required if disease duration less than 3 years)
- Normal levels of vitamin B12
- VDRL negative
- Normal thyroid function
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 14 locations
1
Department of Neurology, Medical University, Innsbruck
Innsbruck, Austria
Active, Not Recruiting
2
Universitätsmedizin Berlin Charité
Berlin, Germany
Actively Recruiting
3
Department of Neurology, University of Bonn
Bonn, Germany, 53105
Actively Recruiting
4
Department of Neurology, University Clinic Essen, University of Duisburg-Essen
Essen, Germany
Actively Recruiting
5
Department of Neurology, University of Frankfurt
Frankfurt, Germany
Actively Recruiting
6
Hamburg UKE Abt. Neuropädiatrie
Hamburg, Germany
Active, Not Recruiting
7
Otto-von-Guericke Universität Magdeburg
Magdeburg, Germany
Actively Recruiting
8
Friedrich-Baur-Institut an der Neurologischen Klinik
München, Germany
Actively Recruiting
9
Universitätsmedidzin Rostock - Klinik und Poliklinik für Neurologie
Rostock, Germany
Actively Recruiting
10
Dept. of Neurodegenerative Diseases Tübingen
Tübingen, Germany
Actively Recruiting
11
Department of Neuroscience, Federico II University Naples
Naples, Italy
Actively Recruiting
12
Universita cattolica del sacro cuore
Rome, Italy
Active, Not Recruiting
13
Radboud University Medical Center, Department of Neurology, Donders Institute for Brain, Cognition, and Behaviour
Nijmegen, Netherlands
Active, Not Recruiting
14
Oslo University Hospital
Oslo, Norway
Actively Recruiting
Research Team
I
Ilaria Anna Giordano, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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