Actively Recruiting
Spot Analysis of Natriuresis to Guide up- or Down-titration of Diuretic Therapy in Ambulatory Patients With Chronic Heart Failure
Led by Cardiology Research UBC · Updated on 2026-03-27
300
Participants Needed
1
Research Sites
112 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Heart failure is a chronic condition that causes congestion and frequent hospitalizations. Diuretic doses are usually adjusted based on clinical judgment without an objective measure of response. This study will test the feasibility of using point-of-care urine sodium measurements to guide up-titration or down-titration of loop diuretics in ambulatory patients with heart failure. Participants will be assigned to one of three groups based on congestion status. Groups 1 and 2 will be randomized 1:1 to natriuresis-guided therapy or standard care. Group 3 will be observational. The 90-day pilot trial will evaluate feasibility, clinical outcomes, and usability of a urine sodium-guided titration strategy.
CONDITIONS
Official Title
Spot Analysis of Natriuresis to Guide up- or Down-titration of Diuretic Therapy in Ambulatory Patients With Chronic Heart Failure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Diagnosis of heart failure according to the Universal Definition
- Use of loop diuretics
- Residing in Vancouver Coastal Health (VCH) or Providence Health Care (PHC) regions
- Group 1: Congestion score 5 or higher OR objective evidence of congestion; stable furosemide use for at least 1 week
- Group 2: New York Heart Association (NYHA) class I-II; congestion score less than 5; no recent heart failure hospitalization; stable furosemide use for at least 1 month
- Group 3: First 100 eligible patients not meeting criteria for Groups 1 or 2
You will not qualify if you...
- Estimated glomerular filtration rate (eGFR) less than 20 mL/min/1.73m²
- Receiving renal replacement therapy
- High-risk clinical status requiring hospitalization
- Unable to consent or perform required urine sampling
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Vancouver General Hospital
Vancouver, British Columbia, Canada
Actively Recruiting
Research Team
N
Natalie Bloch, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
5
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