Actively Recruiting
SRS/SRT/Hypo-RT Versus HA-WBRT for No More Than 10 Brain Metastases in SCLC
Led by Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Updated on 2025-07-16
340
Participants Needed
1
Research Sites
234 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This phase III trial compares the effect of stereotactic radiosurgery and whole brain radiation therapy that avoids the hippocampus (the memory zone of the brain) for the treatment of small cell lung cancer that has spread to the brain.
CONDITIONS
Official Title
SRS/SRT/Hypo-RT Versus HA-WBRT for No More Than 10 Brain Metastases in SCLC
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 80 years with performance status 0-2 or Karnofsky score 70 or higher and expected lifetime over 6 months
- Pathologically confirmed small cell lung cancer diagnosed within 5 years (or more recent confirmation if original diagnosis was over 5 years ago)
- No more than 10 brain metastases, each 5 cm or smaller and 150 ml or less in treated volume, confirmed by MRI within 2 weeks before study
- All brain metastases must be located outside a 5-mm margin around the hippocampus or optic pathways
- Patients not suitable for surgical removal of all brain lesions; partial resection allowed if at least 2 weeks have passed since surgery
- Ability to complete study assessments (cognitive tests, questionnaires) and follow-up for at least 6 months
- At least one measurable brain metastasis according to RECIST 1.1 criteria
- Women of childbearing potential and sexually active men willing to use contraception during treatment and for 180 days after
- Written informed consent provided before enrollment
You will not qualify if you...
- Evidence of new, untreated, or progressing brain metastases before registration
- Previous brain radiotherapy
- Unable to tolerate immobilization or contraindications for MRI (e.g., pacemaker, defibrillator, certain implants)
- Hydrocephalus, ventricular system distortion, leptomeningeal metastases, or increased intracranial pressure needing urgent surgery
- Unrecovered severe toxicities (grade 3 or higher) from prior treatments
- Serious illnesses such as recent heart attack, severe arrhythmia, or psychiatric disorders within past 6 months
- Other active cancers diagnosed within 5 years requiring treatment (excluding certain skin and cervical cancers)
- Pregnant or breastfeeding women
- Participation in another clinical trial or competing study at the same time
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Nan Bi
Beijing, Beijing Municipality, China, 100021
Actively Recruiting
Research Team
N
Nan Bi, M.D
CONTACT
J
Jianyang Wang, M.D
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here