Actively Recruiting
SSTR2 Imaging With [68Ga]Ga-DOTA-TOC PET/CT in NPC
Led by University Medical Center Groningen · Updated on 2025-10-03
10
Participants Needed
1
Research Sites
61 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is an investigator-initiated, single-center clinical trial designed to evaluate the feasibility of \[68Ga\]Ga-DOTA-TOC positron emission tomography (PET) scan in patients with Epstein-Barr virus (EBV) related nasopharyngeal carcinome (NPC) prior to and three weeks after the start of induction chemotherapy or concurrent chemoradiotherapy (CRT). Archival tumor tissue from the diagnostic biopsy will be used to perform somatostatin receptor 2 (SSTR2) immunohistochemistry (IHC). Blood samples will be drawn at baseline, after three weeks, after completion of induction chemotherapy if applicable, and after CRT.
CONDITIONS
Official Title
SSTR2 Imaging With [68Ga]Ga-DOTA-TOC PET/CT in NPC
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Stage IB-IVA nasopharyngeal carcinoma (NPC) confirmed EBV positive by Epstein-Barr virus-encoded RNA (EBER)
- Planned treatment with induction chemotherapy or concurrent chemoradiotherapy without induction chemotherapy
- Age 18 years or older
- Signed informed consent
- Willingness and ability to follow all study procedures
- Negative serum pregnancy test for women able to become pregnant
- Archival tumor tissue available or willing to have a tumor biopsy
You will not qualify if you...
- Previous chemotherapy or radiotherapy treatment for nasopharyngeal carcinoma
- Treatment with investigational agents or participation in another therapeutic clinical trial within 28 days before [68Ga]Ga-DOTA-TOC injection
- Other diseases or conditions that could affect study results or increase risk of complications
- Altered mental status or psychiatric conditions preventing understanding or consent
- Unable to lie on back for 25 minutes
- Pregnant or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University Medical Center Groningen
Groningen, Netherlands, 9713 GZ
Actively Recruiting
Research Team
S
Sjoukje F. Oosting, MD, PhD
CONTACT
F
Fleur van Doorn, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here