The St. Paul's Hospital Advanced Endoscopic Resection Centre Cohort for Colorectal Neoplasia (SPARC-C): A Prospective Observational Study

What this Trial Is About

Researchers are conducting the SPARC-C study, a prospective, multi-institutional observational study focused on patients with large (20mm or larger) non-pedunculated colorectal polyps (LNPCPs). The study aims to evaluate current management strategies for these polyps using minimally invasive endoscopic techniques, while collecting detailed data on patient characteristics, lesion details, procedural outcomes, and clinical results over time. This research is based at multiple hospitals and plans to enroll around 3500 participants over 10 years. Participants undergo endoscopic tissue resection procedures such as endoscopic mucosal resection (EMR), endoscopic submucosal dissection (ESD), or cold snare resection (CSR), which are standard treatments for large colorectal polyps. The study observes how these techniques are applied, including any technical modifications or auxiliary strategies used to reduce risks like bleeding, injury, perforation, or polyp recurrence. The study does not assign treatments but follows patients managed according to current care standards. During the study, participants' outcomes such as technical and clinical success of the endoscopic procedures are monitored, along with adverse events like bleeding or perforation, and rates of recurrence or surgery referral. Data collection includes clinical assessments and procedural details up to 6 months afterward. This long-term observational study helps refine endoscopic management of LNPCPs and supports development of decision support tools using artificial intelligence.

St. Paul's Advanced Resection Center Cohort for Colorectal Neoplasia (SPARC-C)