Actively Recruiting

Phase Not Applicable
Age: 21Years - 70Years
All Genders
Healthy Volunteers
ID05622344

StableEyes With Active Neurophysiological Feedback for Motion Sickness and Vestibular Rehabilitation

Led by Johns Hopkins University · Updated on 2025-11-10

48

Participants Needed

2

Research Sites

N/A

Total Duration

On this page

Sponsors

J

Johns Hopkins University

Lead Sponsor

N

National Aeronautics and Space Administration (NASA)

Collaborating Sponsor

AI-Summary

What this Trial Is About

Researchers are evaluating a self-administered rehabilitation tool designed to help reduce motion sickness and improve balance recovery after centrifugation or surgery affecting the vestibular nerve. This study involves people with vestibular disorders, including those who have had unilateral vestibular schwannoma surgery, as well as healthy individuals with characteristics similar to astronauts. The goal is to assess how guided head movements affect symptoms and recovery. Participants use a device called SWAN that guides sinusoidal head rotations along three axes (yaw, pitch, and roll) for a total of 15 minutes per session. The device encourages users to adjust the movement amplitude based on their level of motion sickness, ranging from none to vomiting. Some participants receive traditional vestibular physical therapy exercises, while others use the automated SWAN method. Healthy controls may receive the SWAN method after motion sickness or no treatment, depending on group assignment. During the study, participants will be monitored daily for up to four weeks. Assessments include motion sickness intensity, eye and head movement measures via video-oculography, heart rate, balance tests with and without head motion, walking speed and endurance, and activity levels. These evaluations help researchers understand changes in vestibular reflexes and overall function. Safety and adherence are tracked throughout the study period.

CONDITIONS

Brief Title

StableEyes With Active Neurofeedback

Who Can Participate

Age: 21Years - 70Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Signed and dated informed consent form
  • Willingness to comply with all study procedures and availability for the study duration
  • In good general health or diagnosed with unilateral vestibular schwannoma
  • Willingness to follow the SWAN and/or vestibular rehabilitation exercises
Not Eligible

You will not qualify if you...

  • Current use of anti-nausea medication
  • Neck problems limiting head motion to less than 30 degrees horizontally or vertically
  • Orthopedic conditions preventing walking or standing independently
  • Legal blindness with vision worse than 20/200
  • Use of investigational motion sickness drugs or behavioral interventions within 30 days before the study

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Treatment

Duration - Daily for up to 4 weeks

Participants receive either traditional vestibular physical therapy exercises or use the SWAN device for guided vestibular rehabilitation to help reduce motion sickness and improve vestibular function.

Daily visits or assessments for up to 4 weeks

Trial Site Locations

Total: 2 locations

1

Johns Hopkins University

Baltimore, Maryland, United States, 21287

Actively Recruiting

2

Naval Medical Research Unit

Dayton, Ohio, United States, 45433

Enrolling by Invitation

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Research Team

M

Michael Schubert, PhD

M

Matthew Stewart, MD PhD

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

4

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Frequently Asked Questions

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Published Research Related To This Trial