Actively Recruiting
Standard Care With or Without Early Palliative Care Provided by a Specialist in Advanced Non-small Cell Lung Cancer Patients A Randomized Controlled Trial
Led by Mahidol University · Updated on 2025-01-22
104
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating advanced non-small cell lung cancer patients to compare the effects of early palliative care provided by a palliative care specialist versus standard care managed by a medical oncologist. This study aims to determine if early palliative care improves quality of life or survival, especially given the availability of newer targeted therapies and immunotherapies that have less toxicity than traditional chemotherapy. The study involves patients with advanced lung cancer starting systemic treatment and considers that oncologists now often provide some palliative care themselves. Participants will be randomly assigned to one of two groups: one group will receive early palliative care by attending a palliative care clinic once a month during the first three months along with their routine oncology visits; the other group will receive only the standard systemic treatment for advanced lung cancer with oncology clinic visits. Both groups will undergo systemic treatment appropriate for their condition. Throughout the study, participants will complete quality of life questionnaires (FACT-L and EQ-5D-5L), a mental health questionnaire (PHQ-9), and pain assessments once a month for three months and again at six months. The primary outcome measured is the quality of life score (FACT-L Total Score) 12 weeks after treatment begins. These assessments help monitor patient well-being and the impact of early palliative care on their health.
CONDITIONS
Official Title
Standard Care With or Without Early Palliative Care Provided by Palliative Care Specialist in Advanced Non-small Cell Lung Cancer Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age at least 18 years old
- Pathologically confirmed advanced non-small cell lung cancer
- Plan to receive systemic treatment for lung cancer within three weeks
- ECOG performance status 0-2 with estimated life expectancy greater than 24 weeks
- Having at least 4 scores according to Edmonton Symptom Assessment System (ESAS)
- Able to complete the questionnaires
You will not qualify if you...
- Had received systemic treatment for advanced lung cancer before
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Trial Site Locations
Total: 1 location
1
Siriraj Hospital
Bangkok, Thailand, 10700
Actively Recruiting
Research Team
L
Lucksamon Thamlikitkul, MD, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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