Actively Recruiting
Standard Dose Continuous Renal Replacement Therapy (CRRT) Versus Low-Dose CRRT ( KETZEREI )
Led by Universität Münster · Updated on 2024-11-27
165
Participants Needed
2
Research Sites
91 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Acute kidney injury (AKI) is a well-recognized complication in critically ill patients, which often leads to the necessity of mechanical kidney support (CRRT). In current therapeutic regimes, CRRT is used to strictly prevent azotaemia. Thus recent clinical observations, as well as data from animal testing suggest a link between controlled azotaemia and faster renal recovery in AKI patients. The aim of the study is to improve renal recovery.
CONDITIONS
Official Title
Standard Dose Continuous Renal Replacement Therapy (CRRT) Versus Low-Dose CRRT ( KETZEREI )
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients (age �3e=18 years)
- Critically ill patients with acute kidney injury needing continuous renal replacement therapy
- Written informed consent
You will not qualify if you...
- Chronic dialysis dependency
- Chronic kidney disease with estimated glomerular filtration rate (eGFR) less than 30 ml/min/1.73m�b2
- Severe liver cirrhosis (Child-Pugh C)
- Severe acidosis (pH less than 7.20 at study enrollment)
- Severe hyperkalaemia (greater than 6 mmol/l)
- Pregnancy or breastfeeding
- Persons held in an institution by legal or official order
- Dependency on the investigator or center
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
University Hospital Münster
Münster, Germany, 48149
Actively Recruiting
2
Universitätsklinikum Tübingen; Universitätsklinik für Anästhesiologie und Intensivmedizin
Tübingen, Germany, 72076
Actively Recruiting
Research Team
A
Alexander Zarbock, MD
CONTACT
M
Melanie Meersch-Dini, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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