Actively Recruiting

Phase 4
Age: 18Years - 70Years
All Genders
Healthy Volunteers
NCT06168214

Standard or Short-course Vonoprazan Non-bismuth Triple Therapy or High-dose Dual Therapy Versus Rabeprazole-bismuth Quadruple Therapy for Primary Helicobacter Pylori Eradication

Led by Xijing Hospital of Digestive Diseases · Updated on 2024-08-13

1404

Participants Needed

1

Research Sites

68 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The goal of this clinical trial is to compare eradication rates of Helicobacter pylori in patients aged 18-70 years with first infection. The main questions it aims to answer are: * Main indicators: the eradication rate of Helicobacter pylori for eradication. * Secondary indicators: symptomatic relief rate at 2 weeks after treatment and 4 weeks after the end of treatment; compliance and adverse reactions during treatment.

CONDITIONS

Official Title

Standard or Short-course Vonoprazan Non-bismuth Triple Therapy or High-dose Dual Therapy Versus Rabeprazole-bismuth Quadruple Therapy for Primary Helicobacter Pylori Eradication

Who Can Participate

Age: 18Years - 70Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 18 to 70 years, any sex
  • Diagnosis of chronic gastritis, peptic ulcer, or dyspeptic symptoms with confirmed Helicobacter pylori infection by positive 13C-urea breath test
  • Willingness to undergo Helicobacter pylori eradication treatment
  • Women of childbearing age must use medically approved contraception during the study and for 1 month after
Not Eligible

You will not qualify if you...

  • Allergy or contraindication to any study drugs
  • Use of proton pump inhibitors within 2 weeks prior to the study
  • Use of antibiotics or bismuth within 4 weeks prior to the study
  • Pregnant or breastfeeding women
  • Previous upper gastrointestinal surgery
  • Refusal to sign informed consent

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Ying han

Xi'an, Shaanxi, China, 710032

Actively Recruiting

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How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

9

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