Actively Recruiting
Standard vs Targeted Oxygen Therapy Prehospital for Chronic Obstructive Pulmonary Disease
Led by Central Denmark Region · Updated on 2025-06-10
1888
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The STOP-COPD trial is a randomized, patient-blinded, prehospital clinical trial designed to evaluate the effect of titrated oxygen therapy compared to standard oxygen treatment in patients with suspected acute exacerbation of chronic obstructive pulmonary disease (AECOPD) treated with inhaled bronchodilators. The primary objective is to determine whether a titrated oxygen strategy targeting SpO₂ 88-92% can reduce 30-day mortality compared to the current standard practice using 100% compressed oxygen as a nebulizer driver.
CONDITIONS
Official Title
Standard vs Targeted Oxygen Therapy Prehospital for Chronic Obstructive Pulmonary Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients over the age of 40
- Suspected acute exacerbation of COPD by emergency medical personnel
- Confirmed suspicion of COPD
You will not qualify if you...
- Bronchospasm caused by asthma, allergic reaction, or non-COPD conditions
- Known or suspected pregnancy
- Use of non-invasive, invasive, or assisted bag mask ventilation before enrollment
- Allergy to inhaled bronchodilators such as Salbutamol
- Inter-hospital transfer
- More than 2 doses (5 mg each) of inhaled bronchodilator treatment given before study treatment
- Suspicion of acute coronary syndrome
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Prehospital Emergency Medical Servises, Central Denmark Region
Aarhus N, Denmark, 8200
Actively Recruiting
Research Team
M
Martin F Gude, PhD
CONTACT
A
Arne Sylvester R Jensen
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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