Actively Recruiting
State of Hormones Impact Nociceptive Expression
Led by University of Alabama at Birmingham · Updated on 2026-03-11
120
Participants Needed
1
Research Sites
178 weeks
Total Duration
On this page
Sponsors
U
University of Alabama at Birmingham
Lead Sponsor
N
National Institute of Nursing Research (NINR)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The Investigators have recently published on differences in pain sensitivity measures between cis and trans individuals in the local area. The investigators observed the anticipated differences in pain sensitivity between CM and CW (CW \> CM), but found that the TW were phenotypically similar to CW in all measures. However, the investigators did not assess hormone level, nor did the investigators recruit TM participants. Here, with the assistance of two local community group stakeholders the investigators will recruit the following groups: CM, CW, TM+T (currently taking exogenous testosterone), TW+E (exogenous estradiol), TM, and TW (n=20/group). The investigators will use quantitative sensory testing to assess sensitivity to cold, pressure, and heat via standardized protocols. Blood samples will be taken for assessment of stress and reproductive hormone levels, immune cell populations and stimulated cytokine release. Finally, questionnaires will measure pain state, quality of life (QOL), voice QOL, body image, appearance, self-reported health, masculinity/femininity, community connectedness, gender role, sleep, depression, social support, adverse childhood experiences and stigma.
CONDITIONS
Official Title
State of Hormones Impact Nociceptive Expression
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Self-identification as one of the specified gender identities
- Age between 18 and 65 years
- Understanding of verbal and written English
- On or off hormone treatment for at least 6 months
You will not qualify if you...
- Experiencing pain on at least 3 days per week for the past 3 months
- HIV positive diagnosis
- Cardiovascular or pulmonary disease
- Regular use of opioid pain medications
- Uncontrolled hypertension (SBP/DBP > 150/95)
- Current illness with fever (body temperature >38 6C)
- History of prostatectomy, hysterectomy, or oophorectomy
- Hospitalization due to psychiatric illness within the last 6 months
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35294
Actively Recruiting
Research Team
T
Tammie Quinn, BA
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
6
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