Actively Recruiting
Stem Cell Analysis, Omics (Including Immunomics) and Artificial Intelligence in Glioblastoma
Led by Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Updated on 2025-03-13
120
Participants Needed
1
Research Sites
147 weeks
Total Duration
On this page
Sponsors
F
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Lead Sponsor
O
Oslo University Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
The study aims at: 1. Perform a multilayer analysis relying on tight integration of in-depth multi-omics approaches with clinical data to discover immune markers, with attention to age and sex differences, predicting prognosis and defining key life/environmental elements, to guide AI-driven personalised treatments and ensure improved care and QoL of glioblastoma patients. 2. To deepen glioblastoma knowledge through the study of glioblastoma stem cell cultures and to assess the sensitivity of glioblastoma stem cell cultures to a number of chemotherapeutics in different experimental conditions. 3. To create a comprehensive, stakeholder-generated guidelines for the ethical use of patient data for artificial intelligence-assisted prediction systems in glioblastoma, including an online, easily accessible patient information brochure to increase patient empowerment in the field.
CONDITIONS
Official Title
Stem Cell Analysis, Omics (Including Immunomics) and Artificial Intelligence in Glioblastoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Radiological diagnosis of supratentorial glioblastoma or first recurrence confirmed by prior surgery
- Candidate for neurosurgery for glioblastoma at Fondazione Policlinico Gemelli IRCCS
- Age 18 years or older
- Provided written informed consent to participate in the study
You will not qualify if you...
- Insufficient pathological material from surgery for routine diagnosis and study use
- Lack of definitive pathological diagnosis of primary supratentorial glioblastoma as per 2021 WHO classification
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Fondazione Policlinico Universitario A. Gemelli IRCCS
Rome, Italy, 00168
Actively Recruiting
Research Team
Q
Quintino Giorgio D'Alessandris, MD, PhD
CONTACT
R
Roberto Pallini, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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