Parent-coached exposure therapy versus cognitive behavior therapy for childhood anxiety disorders.
Stephen P H Whiteside, Bridget K Biggs, Jennifer R Geske...
https://pubmed.ncbi.nlm.nih.gov/38788593/Actively Recruiting
Led by Andrew Wiese · Updated on 2026-03-02
106
Participants Needed
1
Research Sites
34 weeks
Total Duration
Researchers are studying childhood anxiety disorders CAD, which are common and can affect school, friendships, and family life. This trial focuses on a stepped care model that starts with parent-focused treatment to help children with anxiety. The study aims to improve access to effective care by testing a low-intensity, affordable approach that involves parents, addressing barriers like limited providers and high costs. The study compares two treatments Relaxation and Mentorship Training RMT, which includes 14 sessions of relaxation techniques and writing activities, and Stepped Care Targeting Exposure and Parenting for Anxiety STEP-A. STEP-A involves two steps first, parents read a book and attend four therapy sessions while practicing tasks with their child, then responders receive 10 weeks of family-based cognitive behavioral therapy focused on exposures and increasing parental involvement. Participants aged 7 to 17 with diagnosed anxiety disorders will attend therapy sessions and be assessed at multiple time points using anxiety rating scales and clinical interviews. Researchers will track progress before, during, and after treatment, including follow-ups at one month and longer-term caregiver interviews. The study runs until 2028 and seeks to better understand how stepped care works and its benefits for children with anxiety.
CONDITIONS
Stepped Care Treatment for Anxiety Resilience
A
Andrew D Wiese, PhD
J
Jazzmine Ward, BS
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Andrew Wiese
Lead Sponsor
Baylor College of Medicine
Collaborating Sponsor
This table compares participation in this trial with other options available for this condition. The information is drawn from published research and the trial’s study details and is provided for educational purposes only.
| Factors | STEP‑A (stepped‑care exposure with parent involvement) | RMT (relaxation and mentorship) | Standard CBT with exposure (external context) |
|---|---|---|---|
| What it is | Stepped‑care behavioral program: abbreviated SPACE‑based parent‑guided component, followed by parent‑led exposure therapy (PCET) if needed | Multi‑component relaxation plus mentorship protocol used as active comparator | Meta‑analysis supports greater symptom improvement when exposure is emphasized over relaxation |
| Role in the trial | Investigational arm tested against alternative behavioral protocol | Active comparator arm combining relaxation and non‑anxiety specific mentorship | External context only; not part of randomized comparison |
| Primary use | To reduce pediatric anxiety via stepped‑care parent‑involved exposure protocol | To serve as a relaxation‑based comparator for anxiety treatment | Established behavioral therapy involving exposure to reduce anxiety symptoms in children |
| How it is given or performed | Step 1: four 45‑minute parent meetings over 8 weeks using abbreviated SPACE materials; Step 2: ten weekly parent‑led exposure therapy sessions (PCET) with therapist support if needed | Relaxation strategies combined with mentorship elements via relation‑based protocol | Typically 12 one‑hour child‑focused CBT sessions emphasizing exposure exercises |
| Evidence status | Efficacy currently being evaluated in this trial; prior SPACE and PCET evidence suggests promise | Efficacy relative to other behavioral treatments under study | Well‑established efficacy for childhood anxiety disorders |
| Important risks | Risks are behavioral therapy‑typical; specific risks not detailed | Risks are minimal and typical of behavioral sessions | General behavioral therapy risks; CBT considered safe |
| Important limitations | Efficacy and generalizability not yet established; conducted only in Texas and requires parent engagement | Comparator may not reflect typical treatment environments or parental involvement | May require more sessions and leave many youth symptomatic; limited parent engagement |
Disclaimer: This comparison is created with the help of artificial intelligence(AI) and may contain errors or missing information. It is not medical advice and does not mean one option is better or safer than another. Clinical trials are still being studied, and joining a trial is your choice. Please consult your healthcare professional before making any decisions.
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) for diagnostic interview and baseline assessments
Duration - Up to 20 weeks
Participants receive behavioral therapy through either Relaxation and Mentorship Training (RMT) or Stepped Care Targeting Exposure and Parenting for Anxiety (STEP-A). RMT involves 14 sessions of relaxation training over several weeks. STEP-A consists of two steps: Step 1 includes four 45-minute parent sessions across 8 weeks with therapeutic tasks, followed by a 10-week maintenance period; Step 2 includes 10 weekly family-based CBT sessions focusing on exposure and parental involvement.
Weekly or biweekly therapy sessions totaling up to 14 sessions depending on assigned treatment
Duration - Up to 12 weeks after treatment completion
Participants are followed up to assess treatment outcomes and maintenance of effects through caregiver interviews and clinical assessments.
1 to 2 follow-up visits including caregiver interview and clinical evaluations
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
2
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https://pubmed.ncbi.nlm.nih.gov/40946358/Andrew Wiese
Lead Sponsor
Baylor College of Medicine
Collaborating Sponsor