Actively Recruiting
Stereotactic Biopsy Split-Course Radiation Therapy in Diffuse Midline Glioma, SPORT-DMG Study
Led by Mayo Clinic · Updated on 2026-01-20
29
Participants Needed
2
Research Sites
313 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This phase II trial studies the clinical outcomes of hypofractionated radiation therapy in patients with diffuse midline gliomas. This study aims to change the way radiation is delivered, from giving 6 weeks of radiation all at once to giving 2 weeks of radiation. This may determine if there is a difference in the outcome of the treatment, and most importantly, the patients' quality of life.
CONDITIONS
Official Title
Stereotactic Biopsy Split-Course Radiation Therapy in Diffuse Midline Glioma, SPORT-DMG Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 1 year or older (no maximum age)
- Radiologic evidence of diffuse midline glioma of the pons with diffuse infiltration of 50% or more of the pons on MRI
- Presence of at least one brainstem symptom: cranial nerve deficit, long tract sign, or cerebellar sign
- If clinical and radiologic criteria are met, biopsy may not be required
- If criteria are not fully met, brainstem lesion biopsy required for study participation
- Able to undergo MRI of the brain
- Negative urine pregnancy test within 7 days prior to registration for women of childbearing potential
- Primary language of English or Spanish for patient and caregiver
- Patient or caregiver able to provide written informed consent
- Caregiver able to complete questionnaires with or without assistance
- Willing to return to enrolling institution for follow-up during active monitoring phase
You will not qualify if you...
- Previous radiation therapy to the brain
- Previous chemotherapy treatment
- Diagnosis of neurofibromatosis type 1 or 2 (NF1 or NF2)
- Pregnant or nursing women
- Women of childbearing potential unwilling to use adequate contraception
- Severe concurrent illness or systemic disease that would interfere with safety or assessment
- Uncontrolled illness including active infection, congestive heart failure, unstable angina, cardiac arrhythmia, or psychiatric/social issues limiting study compliance
- Other active malignancy within 5 years prior to registration except certain skin, breast, prostate, thyroid cancers, or carcinoma in situ of the cervix
- For patients over 16 years, ECOG performance score of 4 or higher
- For patients 16 years or younger, Lansky play scale score of 20 or less
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Mayo Clinic Hospital in Arizona
Phoenix, Arizona, United States, 85054
Actively Recruiting
2
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
Research Team
C
Clinical Trials Referral Office
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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