Actively Recruiting
Stereotactic Body Radiotherapy vs Conventional Palliative Radiotherapy for Painful Non-Spine Bone Metastases
Led by Canadian Cancer Trials Group · Updated on 2026-03-27
230
Participants Needed
7
Research Sites
147 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is being done to answer the following question: Is Stereotactic Body Radiation Therapy or SBRT (a form of radiation therapy which can deliver high doses of radiation to the specific painful area of the body most affected by cancer, while keeping the radiation beams away from the healthy parts of the body that surround the cancer) better for pain relief than the standard treatment of conventional radiation therapy or CRT (a form of radiation therapy which delivers radiation to the painful area but can also negatively affect other parts of the body in the same area)
CONDITIONS
Official Title
Stereotactic Body Radiotherapy vs Conventional Palliative Radiotherapy for Painful Non-Spine Bone Metastases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologic confirmation of solid tumour
- Presence of a dominant painful non-spine bone metastasis with a worst minimum pain score of 2 or greater
- Expected survival longer than 6 months as assessed by the treating doctor
- Suitable for both SBRT and conventional radiation treatments as defined by the study
- Stable pain without plans to change pain medication
- ECOG performance status between 0 and 2
- Signed informed consent according to local and regulatory rules
You will not qualify if you...
- Bone metastases located in the hands, feet, skull, spine, or sacrum as the primary painful site
- Bone metastases originating from small cell or germ cell tumors
- Radionuclide therapy received within 30 days before randomization
- Prior palliative radiation therapy to the dominant painful bone metastasis site (unless before metastasis development)
- Chemotherapy received within 1 week before or planned within 1 week after radiation therapy
- Unstable pathological fracture at the painful bone metastasis or preference for surgical fixation
- Pregnancy or lactation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 7 locations
1
Kingston Health Sciences Centre
Kingston, Ontario, Canada, K7L 2V7
Actively Recruiting
2
London Health Sciences Centre Research Inc.
London, Ontario, Canada, N6A 5W9
Actively Recruiting
3
Stronach Regional Health Centre at Southlake
Newmarket, Ontario, Canada, L3Y 2P9
Actively Recruiting
4
Odette Cancer Centre
Toronto, Ontario, Canada, M4N 3M5
Actively Recruiting
5
University Health Network
Toronto, Ontario, Canada, M5G 2M9
Actively Recruiting
6
CHUM-Centre Hospitalier de l'Universite de Montreal
Montreal, Quebec, Canada, H2X 3E4
Actively Recruiting
7
Hotel-Dieu de Quebec
Québec, Quebec, Canada, G1R 2J6
Actively Recruiting
Research Team
W
Wendy Parulekar
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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