Actively Recruiting
Stereotactic Boost and Short-course Radiation Therapy for Oropharynx Cancer
Led by Centre hospitalier de l'Université de Montréal (CHUM) · Updated on 2025-05-18
360
Participants Needed
2
Research Sites
509 weeks
Total Duration
On this page
Sponsors
C
Centre hospitalier de l'Université de Montréal (CHUM)
Lead Sponsor
M
M.D. Anderson Cancer Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a randomized clinical trial comparing the outcomes of short-course chemoradiation consisting in stereotactic boost to the gross tumor and de-esclalated chemoradiation to the elective neck in human papilloma associated oropharynx cancer vs. the current standard 7-week course chemoradiation.
CONDITIONS
Official Title
Stereotactic Boost and Short-course Radiation Therapy for Oropharynx Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 218 years
- Ability to provide written informed consent
- Eastern Cooperative Oncology Group (ECOG) performance status 0-2
- Biopsy proven diagnosis of squamous cell carcinoma of the oropharynx
- Positive for HPV by p16 immunohistochemistry or HPV in-situ hybridization
- Clinical stage T1-3, N1 M0 (Stage I-II) as per AJCC 8th edition
- Primary tumor smaller than 30 cc
- Planned for curative chemoradiation
- For females of child-bearing age, a negative pregnancy test
You will not qualify if you...
- Clinical N3 classification as per AJCC 8th edition
- Clinically overt extranodal extension (ENE) defined by invasion of skin, musculature, fixation to adjacent structures, or nerve invasion with dysfunction
- Previous irradiation of the head and neck region
- Previous surgery of the head and neck region except biopsies
- Pregnancy or breastfeeding
- Connective tissue disease
- Any medical condition preventing follow-up after radiotherapy
- Use of non-Cisplatin concurrent chemotherapy
- Prior induction chemotherapy
AI-Screening
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Trial Site Locations
Total: 2 locations
1
London Health Sciences Center
London, Ontario, Canada
Actively Recruiting
2
Centre Hospitalier de l'Université de Montréal
Montreal, Quebec, Canada, H2X 1R6
Actively Recruiting
Research Team
D
Diane Trudel
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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