Actively Recruiting
Stereotactic Post-operative Radiotherapy for Intraparotid Metastatic Cutaneous Squamous Cell Carcinoma
Led by David Palma · Updated on 2026-01-13
90
Participants Needed
1
Research Sites
514 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to compare the effectiveness and side effects of stereotactic radiotherapy (5 sessions) against conventional (standard) radiotherapy (20-30 sessions) for the treatment of skin cancer involving the head and neck after surgical resection. Stereotactic radiotherapy works in the same way that conventional (standard) radiotherapy does to kill cancer cells by damaging their genetic material and stopping the cancer cells from making copies of themselves. This study will help the study doctors find out if this different approach is the same, better, or worse than the standard of care for your cancer.
CONDITIONS
Official Title
Stereotactic Post-operative Radiotherapy for Intraparotid Metastatic Cutaneous Squamous Cell Carcinoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Patient able to provide informed consent
- Eastern Cooperative Oncology Group (ECOG) performance status 0-2
- Candidate for curative intent treatment
- Able to comprehend English to complete patient-reported outcome questionnaires
- Biopsy-confirmed cutaneous squamous cell carcinoma
- Definitive surgical removal of a primary cutaneous tumor in the head and neck
- Tumor stage T1-T4 or unknown primary with positive intraparotid, peri-parotid, or cervical node assumed from head and neck cutaneous SCC
- Nodal stage N1-N3
- At least one indication for adjuvant radiation: T3 or T4 tumor stage, lymphovascular invasion, perineural invasion, positive or close (≤ 3 mm) margin, one or more positive intraparotid, peri-parotid, or cervical lymph nodes, or multiple local recurrences/multifocal disease
- Neoadjuvant or adjuvant immunotherapy allowed
You will not qualify if you...
- Definite metastatic disease at diagnosis
- Pregnant or breastfeeding women
- Significant health conditions or contraindications to surgery and radiation
- History of previous head and neck cancer within 5 years except localized skin cancers without nodal or distant spread
- Prior radiation to the ipsilateral parotid or neck except allowed overlapping radiation for index skin cancer
- Indications for radiation to the opposite neck (contralateral or bilateral lymph nodes)
- Previous invasive malignancy within 5 years unless controlled with no evidence of disease
AI-Screening
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Trial Site Locations
Total: 1 location
1
Verspeeten Family Cancer Centre
London, Ontario, Canada, N6A 5W9
Actively Recruiting
Research Team
P
Palma
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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