Actively Recruiting
Stereotactic Radiotherapy Treatment for Treatment-resistant Depression
Led by Capital Medical University · Updated on 2026-04-27
9
Participants Needed
1
Research Sites
122 weeks
Total Duration
On this page
Sponsors
C
Capital Medical University
Lead Sponsor
C
Chinese PLA General Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study is an clinical trial aimed at evaluating the effectiveness and safety of stereotactic radiotherapy for treatment-resistant depression
CONDITIONS
Official Title
Stereotactic Radiotherapy Treatment for Treatment-resistant Depression
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants aged 18 to 50 years, any gender
- Diagnosed with recurrent major depressive disorder without psychotic features according to DSM-5
- Documented treatment-resistant depression with less than 50% improvement after at least two adequate antidepressant treatments during the current episode
- Hamilton Depression Rating Scale 17-item (HAMD-17) score of 20 or higher at screening and baseline
- Willing to maintain current antidepressant therapy unchanged during the study
- Able and willing to provide informed consent and follow study procedures
You will not qualify if you...
- Diagnosis or history of other DSM-5 mental disorders such as bipolar disorder, schizophrenia, obsessive-compulsive disorder, substance use disorders, or personality disorders
- Significant unstable or severe medical conditions including cardiovascular, respiratory, digestive, endocrine, urinary, hematological, nervous system diseases, or tumors
- Severe neurological diseases or impairments including increased intracranial pressure, brain lesions, stroke, epilepsy (except ECT-induced), cerebral aneurysm, Parkinson's, Huntington's, multiple sclerosis, or severe head trauma
- High suicide risk based on recent suicidal ideation or behavior assessments
- Participation in other neuromodulation therapies or clinical trials recently
- Non-response to systematic MECT treatment
- History of psychosurgical procedures or prior radiotherapy, chemotherapy, immunotherapy, or radiation/toxic exposure
- Contraindications to MRI such as metallic implants, pacemakers, cochlear implants, or claustrophobia
- Pregnant or lactating women or unwillingness to use effective contraception
- Body weight over 150 kg
- Any other condition deemed unsuitable by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Beijing Anding Hospital, Capital Medical University
Beijing, China
Actively Recruiting
Research Team
A
Aihong Yu, Prof., Medical Doctor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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