Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT05761067

STICH-3.0 International Trial Consortium

Led by Vastra Gotaland Region · Updated on 2024-09-25

2800

Participants Needed

1

Research Sites

365 weeks

Total Duration

On this page

Sponsors

V

Vastra Gotaland Region

Lead Sponsor

U

University of Glasgow

Collaborating Sponsor

AI-Summary

What this Trial Is About

The primary objective of the STICH 3.0 Study is to determine whether CABG is superior to PCI in terms of all-cause mortality at 5 years in patients with severe CAD and iLVSD. Individual patient data from similar national RCTs independently powered for different efficacy endpoints will be pooled, harmonized, and analyzed. The primary endpoint is all-cause mortality.

CONDITIONS

Official Title

STICH-3.0 International Trial Consortium

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age >18 years
  • Left ventricular ejection fraction (LVEF) ≤40%
  • Extensive coronary artery disease, typically with a British Cardiovascular Intervention Society jeopardy score of ≥6
Not Eligible

You will not qualify if you...

  • Decompensated heart failure requiring inotropic/adrenergic support, ventilation, or mechanical support within 48 hours before randomization
  • Valvular heart disease or other cardiac conditions needing surgical repair or replacement
  • High bleeding risk or conditions preventing long-term dual antiplatelet therapy
  • Pregnancy
  • Situations likely to cause poor treatment adherence
  • ST-elevation myocardial infarction (STEMI) within 72 hours
  • Percutaneous coronary intervention (PCI) within 3 months

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Dep of Cardiology, Sahlgrenska University Hospital

Gothenburg, Sweden, 41345

Actively Recruiting

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Research Team

B

Björn Redfors, MD, PhD

CONTACT

M

Mark Petrie, MD, PhD, Professor

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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