Actively Recruiting
Stimulation With Bethanechol in Combination With Gemcitabine and Nab-paclitaxel in Pancreatic Adenocarcinoma
Led by Susan E. Bates · Updated on 2025-06-05
37
Participants Needed
1
Research Sites
204 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The primary objective of this study is to assess the impact of bethanechol therapy on R0 resection rates. The safety objective will be assessment of the safety and tolerability of bethanechol in combination with gemcitabine and nab-paclitaxel. The exploratory objective will be to evaluate genomic biomarkers associated with parasympathetic stimulation in pancreatic cancer, and the ability to reduce tumor growth rate.
CONDITIONS
Official Title
Stimulation With Bethanechol in Combination With Gemcitabine and Nab-paclitaxel in Pancreatic Adenocarcinoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of pancreatic ductal adenocarcinoma
- Plan to receive neoadjuvant chemotherapy
- Diagnostic tissue available for biomarker analysis
- Ability to take oral medications and follow study procedures
You will not qualify if you...
- Presence of metastatic disease
- Evidence of gastrointestinal obstruction
- Baseline slow heart rate (heart rate less than 55) or low blood pressure (systolic under 90)
- Current use of acetylcholinesterase inhibitors
- Medical conditions including hyperthyroidism, active or symptomatic coronary artery disease, seizure disorder, or peptic ulcer disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Columbia University Medical Center
New York, New York, United States, 10032
Actively Recruiting
Research Team
R
Research Nurse Navigator
CONTACT
S
Susan E Bates, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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