Actively Recruiting
STOP-UC: De-escalation of Therapy in Patients With Ulcerative Colitis With Histological Remission
Led by University of Chicago · Updated on 2026-04-06
200
Participants Needed
1
Research Sites
102 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this study is to better understand treatment strategies for people with ulcerative colitis (UC). Researchers will compare patients with UC in histologic remission (no evidence of inflammation or active disease on endoscopy and biopsies) who continue to take medical therapy to patients with UC who de-escalate (decrease or discontinue) medical therapy. Both treatment strategies are considered within regular medical practice. Researchers want to find out whether remission can be maintained after de-escalation of therapy. Participants will be: * either be randomly assigned to continue medical therapy or de-escalate medical therapy -OR- be assigned per the participant's preference * clinically managed according to regular medical care * asked to provide blood, stool (poop), and tissue samples for study purposes
CONDITIONS
Official Title
STOP-UC: De-escalation of Therapy in Patients With Ulcerative Colitis With Histological Remission
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Consenting patients aged 18 to 75 years with an established diagnosis of ulcerative colitis for at least 3 years
- Patients in deep remission with no endoscopic or histologic signs of active inflammation in all biopsies within the last 12 months
- If colonoscopy within last 3 years shows stable remission, a persistent normalized calprotectin test is accepted
- Patients in clinical, biochemical (fecal calprotectin <100), radiologic, and endoscopic remission since the last colonoscopy
You will not qualify if you...
- Any active inflammation noted clinically, sonographically, biochemically, or endoscopically in any colonic segment
- Any changes in therapy after colonoscopy showing histological normalization or quiescence
- Corticosteroid use after colonoscopy showing histologic normalization or quiescence
- History of primary sclerosing cholangitis or invisible/unresected high-grade dysplasia
- Pregnancy or actively trying to conceive
- Inability to follow the sample collection and monitoring protocol
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Chicago
Chicago, Illinois, United States, 60637
Actively Recruiting
Research Team
R
Research Coordinator
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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