Actively Recruiting
Strategies to Augment Ketosis: Ketone Conferred Resiliency Against Sleep Restriction
Led by Ohio State University · Updated on 2025-05-29
60
Participants Needed
1
Research Sites
162 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Sleep deprivation is a major problem in military populations. Some major consequences of sleep loss are inability to concentrate, poor work efficiency, and increase in errors during daily tasks. There is some evidence that ketone ester supplements may lessen the adverse effects of sleep restriction. The main purpose of these supplements is to raise your blood concentration of ketones, which are safe, small molecules that appear in the blood during fasting, when following a ketogenic diet, or consuming ketone supplements. The main purpose of this study is to examine if ingesting a ketone ester supplement, twice daily, can improve cognitive and physical performance during short-term sleep restriction.
CONDITIONS
Official Title
Strategies to Augment Ketosis: Ketone Conferred Resiliency Against Sleep Restriction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Willing and able to comply with study procedures including fasting (>10 hours, water only), no alcohol (>24 hours), no exercise (>24 hours), no acute illness, controlled feeding before each test day, and maintaining diet, exercise, medication, and supplement habits throughout the study
- No health conditions preventing study completion as judged by the Investigator
- Understands study procedures and provides informed consent including authorization to release relevant health information
You will not qualify if you...
- Younger than 18 or older than 40 years of age
- Body mass index (BMI) over 35
- Diagnosed sleep disorders such as sleep apnea or insomnia
- Gastrointestinal disorders or food allergies interfering with supplement consumption
- Consumes alcohol in excess of 3 drinks per day or 14 drinks per week
- Conditions or contraindications preventing blood draws
- Diagnosed with diabetes, liver, kidney, or other metabolic or endocrine dysfunction, or uses diabetic medications other than metformin
- Currently or recently (within 3 months) on a low carbohydrate or ketogenic diet
- Experienced weight loss greater than 10% of body weight in the last 6 months
- Pregnant, lactating, or planning pregnancy during the study
- Major psychiatric disorders such as schizophrenia or bipolar disorder
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The Ohio State University
Columbus, Ohio, United States, 43210
Actively Recruiting
Research Team
J
Jeff S Volek, PhD
CONTACT
M
Madison L Kackley, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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