Actively Recruiting
Stratified vs Routine Prophylaxis in Living Kidney Transplantation From HBsAg+ Donors to HBsAg- Recipients
Led by West China Hospital · Updated on 2023-11-29
100
Participants Needed
1
Research Sites
298 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a multicenter, prospective, observational study to compare the efficacy and safety of stratified prophylaxis based on donors' and recipients' risk factors vs routine prophylaxis bases on clinical experience in living kidney transplantation from HBsAg+ donors to HBsAg- recipients. The follow-up period was 2 years after renal transplantation. The primary outcome was prevention failure of HBV transmission (any one of HBsAg - → +, HBV DNA - → +, HBeAg - → +, HBeAb - → +, HBcAb - → +, active liver function damage and death in the recipient).
CONDITIONS
Official Title
Stratified vs Routine Prophylaxis in Living Kidney Transplantation From HBsAg+ Donors to HBsAg- Recipients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients diagnosed with end-stage renal disease and suitable for living kidney transplantation
- Donor is HBsAg positive and is the only donor
- No age or sex restrictions for donors and recipients
- Donor and recipient can be ABO compatible or incompatible
- Living donor donates one kidney voluntarily and free of charge
- Both donor and recipient understand the purpose and risks and sign informed consent
- Study approved by ethics committee
You will not qualify if you...
- Donor or recipient has abnormal liver function before surgery (ALT > 60 IU/L for females, > 75 IU/L for males; or total bilirubin > 34 umol/L)
- Donor or recipient has liver cirrhosis shown by ultrasound
- Positive complement-dependent cytotoxicity cross-match test
- Donor or recipient infected with HCV or HIV
- Diagnosed with malignancy or history of malignancy within last 5 years
- History of kidney transplantation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Tao Lin
Chengdu, Sichuan, China, 610041
Actively Recruiting
Research Team
T
Tao Lin, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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