Actively Recruiting
Stratifying Critically Ill Patients for Novel Ferroptosis or Pyroptosis Intervention Strategies
Led by University Hospital, Antwerp · Updated on 2025-04-15
600
Participants Needed
1
Research Sites
124 weeks
Total Duration
On this page
Sponsors
U
University Hospital, Antwerp
Lead Sponsor
U
Universiteit Antwerpen
Collaborating Sponsor
AI-Summary
What this Trial Is About
In order to better determine which therapy is best for patiënts which present with organ falure during the course of their stay in the intesive care unit (ICU) , one has to determine which underlying mechanism is causing this organ falure. We will determine levels of so called "biomarkers" for ferroptosis (a mechan ism of iron-related cell death) in the peripheral blood and biological fluids of criticaly ill patients admitted to the ICU with a catastrrophy (severe infection, trauma ...) . Why ? If it turns out that this ferroptosis plays a role in the ocurrence of organ failure in the critially ill, this will lead to new therapies in the future as drugs become more and more available which can influene this biochemical "pahway". of iron-relatd death.
CONDITIONS
Official Title
Stratifying Critically Ill Patients for Novel Ferroptosis or Pyroptosis Intervention Strategies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Admitted to the ICU of UZA
- Critically ill and expected to stay in the ICU for more than 48 hours (mostly patients admitted for sepsis, trauma, hemorrhagic shock, neurological catastrophe)
- Have an arterial line in place for blood sampling
You will not qualify if you...
- Refusal of consent by patient or closest relative
- Postoperative patients after major surgery where prolonged ICU stay is not expected (e.g., elective cardiac surgery)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University Hospital Antwerp
Edegem, Belgium, 2650
Actively Recruiting
Research Team
T
Tom Stroobants, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here