Actively Recruiting
Streamlining Radioembolization for Small HCC
Led by Seoul National University Hospital · Updated on 2026-04-09
146
Participants Needed
4
Research Sites
237 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
In patients who has no sign suggesting high lung shunt fraction (TIPS, hepatic vein invasion, hepatic vein enhancement on arterial phase, dysmorphic intratumoral vessel, tumor size \< 5cm), radioembolization is performed without MAA scan with SIR-Spheres. This prospective registry will prove that the selection criteria is accurate and streamlining radioembolization is feasible and safe.
CONDITIONS
Official Title
Streamlining Radioembolization for Small HCC
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged >18 years
- Diagnosed with hepatocellular carcinoma histologically and/or radiologically (LI-RADS 4 or 5)
- Hepatocellular carcinoma 5 cm or smaller
- Tumor number is 3 or smaller
- Dysmorphic intratumoral vessel is absent or smaller than 3 mm
- Child-Pugh class A
- ECOG performance status 0 or 1
- Laboratory values must meet: Leukocytes ≥ 1,000/µL and ≤ 20,000/µL, Hemoglobin ≥ 6.0 g/dL (transfusion allowed), Total bilirubin ≤ 2.0 mg/dL, Platelet count ≥ 40,000/µL, INR ≤ 2.0 if not on anticoagulants, AST ≤ 800 IU/L, ALT ≤ 800 IU/L, Creatinine ≤ 2.5 mg/dL (no upper limit if on hemodialysis)
- Life expectancy greater than 3 months
- Able to understand the clinical trial and provide written consent
- Nonpregnant women of childbearing potential
You will not qualify if you...
- Hepatic vein invasion seen on CT or MRI
- Marked enhancement of portal vein or hepatic vein on arterial phase of CT or MRI
- Dysmorphic intratumoral vessel 3 mm or larger
- Presence of transjugular intrahepatic portosystemic shunt (TIPS)
- Bilioenteric anastomosis or biliary stent
- Centrilobular emphysema or interstitial lung disease
- Main portal vein invasion
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
National Cancer Center
Goyang, South Korea
Actively Recruiting
2
Samsung Medical Center
Seoul, South Korea
Not Yet Recruiting
3
Seoul National University Hospital
Seoul, South Korea
Actively Recruiting
4
Severance hospital
Seoul, South Korea
Not Yet Recruiting
Research Team
H
Hyo-Cheol Kim, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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