Resistance training for hot flushes in postmenopausal women: A randomised controlled trial.
Emilia Berin, Mats Hammar, Hanna Lindblom...
https://pubmed.ncbi.nlm.nih.gov/31239119/Actively Recruiting
Led by Linkoeping University · Updated on 2025-01-22
90
Participants Needed
2
Research Sites
287 weeks
Total Duration
This research aims to compare the effects of two types of physical exercisestrength training and high-intensity aerobic exerciseagainst unchanged physical activity on vasomotor symptoms, specifically hot flushes, in postmenopausal women. The study also evaluates secondary outcomes like quality of life, sleep quality, physical activity levels, clinical and biomarker changes, bone markers, and bone mineral density. Researchers hope to find safe, evidence-based options to improve health and quality of life after menopause. Participants are randomly assigned to one of three groups strength training, high-intensity aerobic training, or a control group with no change in physical activity. The exercise interventions include a 3-week adaptation period followed by 12 weeks at the intended load or intensity, with sessions recommended three times per week for one hour. Strength training involves specific machine exercises with progressive loads, while aerobic training includes spinning classes progressing to high intensity. The control group continues usual activity and receives follow-up support. Participants undergo screening visits to confirm eligibility and keep a diary of hot flushes before randomization. Throughout the 15-week study, various assessments are done including diaries, questionnaires, clinical exams, body measurements, blood tests, bone density scans, and exercise capacity tests. Researchers will monitor adherence to training and collect data on hot flush frequency and severity, quality of life, physical activity, and other health markers. Safety and adverse events are also tracked during the study.
CONDITIONS
Strength and Aerobic Training Against Hot Flushes in Postmenopausal Women
A
Anna-Clara Spetz Holm, Ass prof, MD
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Linkoeping University
Lead Sponsor
Region Östergötland
Collaborating Sponsor
You may qualify if you...
You will not qualify if you...
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
2 visits (in-person): initial screening visit and a second visit 2-3 weeks later for inclusion and randomization if criteria are met
Duration - 3 weeks
Participants in the intervention groups complete a 3-week adaptation period with lower loads or intensity before starting the main training.
Participants exercise three times per week, 1 hour each session
Duration - 12 weeks
Participants complete a 12-week period of either strength training, high-intensity aerobic training, or maintain usual physical activity in the control group.
Participants exercise three times per week, 1 hour each session; control group contacted every 4 weeks by phone
Duration - Up to 5 years
Participants are monitored for long-term effects on vasomotor symptoms and other health outcomes up to 5 years after intervention.
Assessments at 6 months, 1 year, 2 years, and 5 years after intervention
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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Emilia Berin, Mats Hammar, Hanna Lindblom...
https://pubmed.ncbi.nlm.nih.gov/31239119/Linkoeping University
Lead Sponsor
Region Östergötland
Collaborating Sponsor