Actively Recruiting
Strengthening the Evidence for Policy on the RTS,S/AS01 Malaria Vaccine
Led by Kintampo Health Research Centre, Ghana · Updated on 2025-02-28
9280
Participants Needed
4
Research Sites
184 weeks
Total Duration
On this page
Sponsors
K
Kintampo Health Research Centre, Ghana
Lead Sponsor
E
European Vaccine Initiative
Collaborating Sponsor
AI-Summary
What this Trial Is About
The ongoing Malaria Vaccine Pilot Evaluation (MVPE) is being conducted in Ghana, Malawi and Kenya through community and sentinel hospital surveillance systems and a series of household surveys (to measure vaccine coverage). The Malaria Vaccine Pilot Evaluation-Case Control (MVPE-CC) registered here as observational study is embedded within MVPE comprising case-control studies of clinical and mortality outcomes. Each case will require four controls, and caregiver informed consent will be required prior to study activities. These observational case control studies will measure as complementary information to what is being collected through MVPE: 1. Safety among children who received the malaria vaccine, with focus on cerebral malaria, meningitis and severe malaria 2. The impact of the malaria vaccine on all-cause mortality for boys and girls, AND 3. Promote use of case-control approaches by Expanded Programmes on Immunization (EPI) and malaria control programmes.
CONDITIONS
Official Title
Strengthening the Evidence for Policy on the RTS,S/AS01 Malaria Vaccine
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Willingness to participate in study evidenced by written informed consent provided by an adult caregiver
- Resident in an RTS,S/AS01 implementation area within the catchment area of MVPE sentinel hospitals
- Eligible, based on date of birth and age, to have received RTSS/AS01
- Meets the case or control definitions above.
You will not qualify if you...
- Caregiver not willing to provide consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
Kintampo Health Research Centre
Kintampo, Ghana
Actively Recruiting
2
African Research Collaboration for Health Limited
Nairobi, Kenya
Actively Recruiting
3
Kenya Medical Research Institute (KEMRI)
Nairobi, Kenya
Actively Recruiting
4
College of Medicine, University of Malawi
Blantyre, Malawi
Actively Recruiting
Research Team
T
Thomas Gyan
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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