Stress Echo 2030 Study Using the ABCDE Protocol to Improve Imaging for Heart Diseases Including Coronary Artery Disease, Heart Failure, and More A Global Effort to Standardize and Enhance Stress Echocardiography

What this Trial Is About

Researchers are investigating a new approach to heart stress imaging called the ABCDE protocol, developed from the previous SE 2020 study. This international, multicenter study focuses on various heart conditions including coronary artery disease, heart failure with preserved ejection fraction, hypertrophic cardiomyopathy, valvular heart disease, and complications after chest radiotherapy, chemotherapy, or COVID-19. The study aims to enroll over 10,000 patients from multiple countries and labs, following them for at least five years to improve stress echocardiography as a versatile diagnostic tool. The study uses different types of stress echocardiography, including physical, pharmacologic, and pacing stress tests, with a standardized ABCDE protocol to assess heart function. Participating labs will use AI software and ultrasound enhancing agents to support uniform testing and data collection. The study also includes specialized projects targeting specific conditions such as repaired Tetralogy of Fallot, heart donors, and coronary vasospasm, all integrated under the ABCDE-SE platform. Participants will undergo regular clinical follow-ups with detailed data collection on demographics, lifestyle, imaging, and cardiovascular events. The study measures important outcomes like all-cause death, cardiac death, and cancer diagnosis over five years. Data on environmental factors and medical radiation exposure will also be analyzed. This approach aims to provide strong evidence for the use of stress echocardiography as a low-cost, radiation-free, and accessible test for patients worldwide.

Stress Echo 2030: the Novel ABCDE-(FGLPR) Protocol to Define the Future of Imaging