Personalized Nutrition and Metabolomics Study on Stress and Obesity in Adolescents Aged 11 to 17

What this Trial Is About

Researchers are exploring the relationship between stress, diet, gut microbiome, and obesity in adolescents aged 11 to 17 years. The study aims to develop personalized dietary interventions for overweight or obese adolescents by understanding how emotional stress and diet influence the gut microbiome and fecal metabolome. This observational study will collect biological samples and questionnaire data to analyze these factors and their impact on weight conditions. Participants will provide saliva, stool, and hair samples collected at home, along with completing questionnaires on mental health, medical history, and diet. The study includes targeted and untargeted metabolomics analysis of fecal samples, microbiome sequencing, and dietary assessments through food frequency questionnaires and 24-hour recalls. A personalized dietary intervention will be conducted for up to 20 overweight or obese adolescents over three months, with individual menus prepared by a dietician based on study findings. During the study, participants will undergo measurements including height, weight, fat percentage, and waist circumference. Blood samples will be collected before and after the intervention to analyze clinical biomarkers such as glucose and cholesterol. Questionnaires will assess emotional eating, physical activity, sleep, and quality of life. The research team will monitor metabolomics, microbiome profiles, stress levels via hair cortisol, and dietary habits throughout the study, which is expected to continue until 2027.

The Stress-obesity Axis: a Metabolomics Approach Towards Personalized Nutrition in Adolescents