Actively Recruiting
The Stress-obesity Axis: a Metabolomics Approach Towards Personalized Nutrition in Adolescents
Led by University Ghent · Updated on 2024-04-30
750
Participants Needed
7
Research Sites
285 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The ultimate aim of this project is to establish a validated strategy that allows for personalized intervention in adolescents (11 to 17 years) whom are assigned a state of overweight or obesity. The investigators will assess the following hypotheses: * Weight condition is reflected by the fecal metabolome (WP1) * Emotional stress is implicated in weight condition (WP1) * Functionality of the gut microbiome is related to the diet-stress-obesity axis (WP2) * Dietary pattern impacts the fecal metabolome and gut microbiome (WP2) * Personalized dietary intervention outperforms generalized dietary approaches (WP3) Participants will: * Produce a saliva, stool and hair sample * Fill in questionnaires regarding mental health, medical health and demographic information * Fill in a food frequency questionnaire and a 24-hrecalls * Be measured (height, weight, fat% and waist circumference) The samples will be analyzed using a technique called metabolomics to identify biomarker candidates with diagnostic and/or prognostic potential. Additionally, microbiome analysis will be performed to map the microbiome of all groups.
CONDITIONS
Official Title
The Stress-obesity Axis: a Metabolomics Approach Towards Personalized Nutrition in Adolescents
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 11 to 17 years
You will not qualify if you...
- Overweight or obesity
- Type 1 diabetes
- Medical conditions including pancreatic failure
- Developmental and hormonal disorders such as thyroid problems, adrenal problems, Kallmann's syndrome, Klinefelter's syndrome, Prader-Willi syndrome, or Congenital hypogonadotropic hypogonadism
- Pregnancy
- Treatment with systemic corticosteroids (e.g., cortisone, betamethasone, dexamethasone, fludrocortisone, hydrocortisone) in pill form or injections
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 7 locations
1
AZ Jan Palfijn Gent, Oost-Vlaanderen, Belgium, 9000
Ghent, Oost-Vlaanderen, Belgium, 9000
Actively Recruiting
2
Ghent University Hospital
Ghent, Oost-Vlaanderen, Belgium, 9000
Actively Recruiting
3
Clairs Vallons
Ottignies-Louvain-la-Neuve, Waals Brabant, Belgium, 1340
Actively Recruiting
4
Zeepreventorium
De Haan, West-Vlaanderen, Belgium, 8420
Actively Recruiting
5
AZ Delta
Roeselare, West-Vlaanderen, Belgium, 8800
Actively Recruiting
6
UZ Antwerpen
Antwerp, Belgium, 2000
Actively Recruiting
7
ZNA Middelheim
Antwerp, Belgium, 2000
Actively Recruiting
Research Team
E
Emile Callemeyn, Dr
CONTACT
L
Lynn Vanhaecke, Prof
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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