Actively Recruiting
Stress and Opioid Misuse Risk: The Role of Endogenous Opioid and Endocannabinoid Mechanisms
Led by Vanderbilt University Medical Center · Updated on 2025-10-21
120
Participants Needed
1
Research Sites
230 weeks
Total Duration
On this page
Sponsors
V
Vanderbilt University Medical Center
Lead Sponsor
N
National Institute on Drug Abuse (NIDA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to see how stress influences the effects of opioid pain medications often used to help relieve back pain. The study will help to learn more about how high stress levels could increase risk for pain medication misuse.
CONDITIONS
Official Title
Stress and Opioid Misuse Risk: The Role of Endogenous Opioid and Endocannabinoid Mechanisms
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Intact cognitive status and ability to provide informed consent
- Ability to read and write in English sufficiently to understand and complete study questionnaires
- Age 18 or older
- Persistent daily low back pain lasting at least three months
- Average low back pain intensity of at least 3 out of 10
You will not qualify if you...
- History of kidney or liver dysfunction
- Current or past alcohol or substance abuse or treatment
- History of PTSD, psychotic, or bipolar disorders
- Chronic pain from cancer or autoimmune diseases like rheumatoid arthritis or lupus
- Recent benzodiazepine use (confirmed by urine test before each lab session)
- Medical conditions contraindicating lab stressors as judged by study physician
- Daily opioid use within past 6 months or opioid use within 3 days before study (confirmed by urine test)
- Pregnancy (confirmed by test before each lab session)
- Prior allergic reaction or intolerance to oxycodone or similar drugs
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37212
Actively Recruiting
Research Team
S
Stephen Bruehl, PhD
CONTACT
G
Gail Mayo
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here