Actively Recruiting
Stress and Pain in People Living With HIV
Led by Yale University · Updated on 2026-04-27
120
Participants Needed
1
Research Sites
263 weeks
Total Duration
On this page
Sponsors
Y
Yale University
Lead Sponsor
N
National Institute on Drug Abuse (NIDA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a basic human experimental study utilizing 4 groups of individuals with and without HIV and complex morbidities of cannabis use disorder and major depression who will participate in 2 sessions of the Yale Pain Stress Task (YPST) and follow-up phase to assess drug use and mood symptoms.
CONDITIONS
Official Title
Stress and Pain in People Living With HIV
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Good health as verified by screening examination
- Able to read English and complete study evaluations and provide informed consent
- HIV-1 lab test positive with undetectable viral load and good ART adherence (for PLWH groups)
- For PLWH with cannabis use disorder and depression: positive cannabis urine test and meet DSM-5 criteria for cannabis use disorder and major depression
- For healthy controls: HIV-1 test negative, urine toxicology negative, no major medical or psychiatric diagnoses
- For PLWH only group: HIV-1 positive, urine toxicology negative, no major medical or psychiatric diagnoses
- For cannabis use disorder only group: HIV-1 test negative, urine toxicology positive, meet DSM-5 criteria for cannabis use disorder and major depression
You will not qualify if you...
- Current moderate or severe substance use disorder for cocaine, alcohol, opiates, sedatives, or nicotine
- Current or past cocaine or opioid use disorder
- History of any psychotic disorder
- Current diagnosis of bipolar disorder or PTSD
- Severe psychiatric disability including suicidal or homicidal ideation or current mania
- Significant medical conditions affecting brain, kidneys, thyroid, or heart
- Use of medications affecting HPA axis or immune function
- Women who are pregnant, nursing, or using hormonal birth control affecting cortisol responses
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The Yale Stress Center
New Haven, Connecticut, United States, 06519
Actively Recruiting
Research Team
R
Rachel Hart, MA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
4
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here