Actively Recruiting
Stress Phenotypes and Preterm Birth
Led by Columbia University · Updated on 2026-05-14
200
Participants Needed
1
Research Sites
311 weeks
Total Duration
On this page
Sponsors
C
Columbia University
Lead Sponsor
N
National Institute on Minority Health and Health Disparities (NIMHD)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Pregnancy ends in preterm birth (PTB) for approximately 1 in 10 women, though more often for Non-Hispanic Black women, 14.12% PTB rate, compared to 9.09% for Non-Hispanic White women. Psychosocial stress and childhood trauma each are associated with risk for PTB and PTB has an intergenerational impact: mothers born preterm are more likely to give birth preterm, especially amongst Black women. In this project, we will study mitochondria, which contain their own genome, the mitochondria DNA, and are inherited from the mother, as they represent a potential intersection point between psychosocial experiences and their biological embedding in underlying disease outcomes such as PTB
CONDITIONS
Official Title
Stress Phenotypes and Preterm Birth
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pregnant women 18 years of age or older
- Not currently smoking, drinking alcohol, or taking drugs
- Planning to deliver at Columbia University Irving Medical Center or New York Presbyterian Hospital
- In the first or second trimester of pregnancy (prior to 28 weeks gestation)
You will not qualify if you...
- Multi-fetal pregnancy
- Taking medications regularly that affect cardiovascular and inflammatory systems, including NSAIDs (except low-dose aspirin), alpha blockers, beta blockers, corticosteroids, and chronic-use asthma medications
- Having inflammatory conditions such as rheumatoid arthritis, lupus, or multiple sclerosis
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Columbia University Irving Medical Center
New York, New York, United States, 10032
Actively Recruiting
Research Team
C
Catherine Monk, PhD
CONTACT
E
Elizabeth Werner, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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