Actively Recruiting
Stress Trajectories and Anhedonia in Adolescence Research Study
Led by University of North Carolina, Chapel Hill · Updated on 2025-06-27
192
Participants Needed
1
Research Sites
255 weeks
Total Duration
On this page
Sponsors
U
University of North Carolina, Chapel Hill
Lead Sponsor
N
National Institute of Mental Health (NIMH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This project will examine how multiple biological measures from the brain and the body's stress response system contribute to anhedonia (the loss of pleasure) in adolescence. The goal of this project is to see if it is possible to combine these biological measures to describe different patterns of activity in the brain and body that adolescents may have in response to stress. The main question this study aims to answer is whether different patterns of activity in the brain and body are related to whether adolescents develop anhedonia and how high or low levels of anhedonia are over time. This study will enroll 192 adolescents who are between 13 and 15 years. Adolescents will complete tasks three times: at the beginning of the study, 10 months after that, and then 10 months after that. In total, they will be part of the study for 20 months. At each time, adolescents will complete surveys, provide samples of spit to measure hormones and provide pictures of their brain to measure brain activity, participate in mildly stressful tasks, and complete different activities that measure how they think. The investigators will also ask each adolescent's parent or legal guardian to answer some surveys about themselves and their child.
CONDITIONS
Official Title
Stress Trajectories and Anhedonia in Adolescence Research Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 13-15 years old at study entry
- Ability to understand and sign an assent form
- Meets study hearing and vision requirements
You will not qualify if you...
- Current use of antipsychotic medication
- Current use of medications that would interfere with cardiovascular or endocrine assessments
- Metal in the body or other MRI exclusion
- Central nervous system disorder or brain injury that could confound brain imaging evaluations
- Presence of a medical condition that would interfere with cardiovascular or endocrine assessments
- Impaired intellectual functioning
- Diagnosed with a neurodevelopmental disability
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States, 27599
Actively Recruiting
Research Team
C
Clinical Research Coordinator
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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