Optimizing CPAP Therapy Support for Stroke Patients with Sleep Apnea During Inpatient Rehabilitation

What this Trial Is About

Researchers are evaluating the effectiveness of an intensive support program for Continuous Positive Airway Pressure CPAP therapy compared to usual care in stroke patients who have obstructive sleep apnea OSA during inpatient rehabilitation. This multicenter randomized controlled trial involves about 250 participants recruited over approximately three years from two inpatient rehabilitation centers. The study aims to see if the intensive support program improves CPAP use and stroke recovery as measured by adherence and the modified Rankin Scale. Participants with OSA are randomly assigned to either an Intensive Support group or a Standard Support group. The Intensive Support group receives a multicomponent behavioral adherence program including CPAP technical support, Motivational Enhancement Therapy, a mobile health app called myAir, tailored text messaging, and educational materials. Both groups receive basic supportive treatments such as CPAP education, respiratory therapy, nursing support during rehabilitation, and referral to durable medical equipment companies as needed. CPAP therapy is started during inpatient rehabilitation and is continued for three months. During the study, CPAP use is electronically measured to track average nightly use over the 90-day period. Stroke recovery is evaluated with the Modified Rankin Scale at three months by phone. Participants receive monthly phone follow-ups for adherence support, and researchers monitor CPAP use, recovery, and safety outcomes. The total participation includes inpatient rehabilitation and a three-month treatment period with ongoing assessments.

Stroke and CPAP Outcome Study 3 Randomized Controlled Trial