Actively Recruiting

Phase Not Applicable
Age: 19Years - 80Years
All Genders
NCT06604143

Stroke Motor Recovery for the Hand and Fingers

Led by University of Toronto · Updated on 2026-05-08

40

Participants Needed

5

Research Sites

86 weeks

Total Duration

On this page

Sponsors

U

University of Toronto

Lead Sponsor

H

Heart and Stroke Foundation of Canada

Collaborating Sponsor

AI-Summary

What this Trial Is About

The goal of this clinical trial is to compare two rehabilitation methods to improve finger movements in people who have had a stroke. The main question it aims to answer is which of these two training methods leads to the most improvement: 1. Teaching people to reach their movement goals using any strategies they like. 2. Teaching people to improve their movement technique and avoid compensatory strategies. There is no one-size-fits-all approach. The second goal is to find out who might benefit more from each method. Some people with stroke may rely on compensatory strategies due to severe impairment, while others with milder strokes might benefit more from techniques that enhance movement quality. The third goal is to take pictures of the brain to see how it changes with each method. This will help researchers understand how the brain adapts after a stroke and could lead to treatments that target the brain directly. Participants will: 1. Visit the lab for clinical and research assessments on weeks 1, 4, 5, and 15. 2. Complete 10 days of piano training. 3. Undergo magnetic resonance imaging (MRI) scans twice, once in week 1 and once in week 4.

CONDITIONS

Official Title

Stroke Motor Recovery for the Hand and Fingers

Who Can Participate

Age: 19Years - 80Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Over 18 years of age
  • Diagnosis of first-time unilateral ischemic or hemorrhagic stroke
  • Stroke occurred more than 6 months and less than 2 years ago
  • Able to perform active finger movements (Chedoke-McMaster Hand Impairment Stage �3 3)
Not Eligible

You will not qualify if you...

  • History of developmental, neurological, or major psychiatric disorders
  • Cognitive deficits (Montreal Cognitive Assessment score less than 23/30)
  • Apraxia (below 2 standard deviations on the Waterloo Apraxia test)
  • Neglect (Sunnybrook Neglect Assessment score greater than 40/100)
  • Cerebellar stroke
  • Musculoskeletal injury affecting motor performance
  • Inability to sit in a chair and perform exercises for sustained periods
  • Contraindications to MRI

AI-Screening

AI-Powered Screening

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Trial Site Locations

Total: 5 locations

1

University of Toronto

Toronto, Ontario, Canada, M5S 2W6

Actively Recruiting

2

Jewish Rehabilitation Hospital

Laval, Quebec, Canada, H7V 1R2

Actively Recruiting

3

University Institute for Physical Impairment Rehabilitation of Montreal (IURDPM)

Montreal, Quebec, Canada, H3S 2J4

Actively Recruiting

4

Lethbridge-Layton-Mackay Rehabilitation Center

Montreal, Quebec, Canada, H4B 1T3

Actively Recruiting

5

Jewish General Hopsital

Montreal, Quebec, Canada, H7V 1R2

Actively Recruiting

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Research Team

J

Joyce L Chen, PhD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

TRIPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

BASIC_SCIENCE

Number of Arms

2

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