Actively Recruiting
StrokeCog-BBB to Study Cognitive Outcomes Following Stroke
Led by Stanford University · Updated on 2024-04-18
350
Participants Needed
1
Research Sites
293 weeks
Total Duration
On this page
Sponsors
S
Stanford University
Lead Sponsor
U
University of Manchester
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to learn about cognitive outcomes in stroke patients. The main question it aims to answer are: 1. Is blood-brain barrier permeability compromised for years after stroke, 2. Is a blood biomarker of imbalanced angiogenesis dysregulated in chronic stroke and 3. Are there biomarkers that separately or together predicts cognitive decline after stroke, and are other MRI, blood, and clinical characteristics that are associated. Participants will undergo cognitive testing and MRIs two years apart. Researchers will compare cognitive outcomes in non-stroke patients who have cardiovascular risk factors to understand the effects of stroke on these outcomes.
CONDITIONS
Official Title
StrokeCog-BBB to Study Cognitive Outcomes Following Stroke
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 45 years or over
- Have one or more vascular risk factors such as high blood pressure, diabetes, or vascular disease like angina, previous heart attack, heart bypass, or peripheral artery disease
- Established vascular disease (previous myocardial infarction, angina, or vascular stent in peripheral arteries)
- Sufficiently fluent in written and spoken English
- Living independently in the community
- Willing and able to give consent to participate in the study
You will not qualify if you...
- Currently treated with IL-1 blockade or immune-suppressant therapy, or treated within the last 3 months
- Currently participating in a clinical trial of investigational medicinal product or device trial
- No history of previous ischemic or hemorrhagic stroke, mini-stroke, or serious brain injury
- Diagnosed with dementia
- Have renovascular disease
- Have major neurological disease such as immune-mediated disorders or previous brain tumors
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Stanford University Hospital
Palo Alto, California, United States, 94304
Actively Recruiting
Research Team
M
Muhith Musabbir
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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