Actively Recruiting
Strontium-Hydroxyapatite Coated Mini-Screws: Antibacterial Effect and Stability
Led by Mansoura University · Updated on 2025-08-26
20
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This randomized controlled clinical trial aims to evaluate the antibacterial efficacy and stability of strontium-incorporated hydroxyapatite (Sr-HA) coated orthodontic mini-screws (OMSs) used for maxillary canine retraction. A double-blind, split-mouth design was employed, involving 20 patients (aged 16-20 years), each receiving two titanium alloy mini-screws (1.6 mm × 8 mm): one coated with Sr-HA (5% concentration via electrochemical deposition) and one uncoated control. A total of 40 mini-screws were assessed. Following upper first premolar extractions, canine retraction was initiated using 150 g NiTi coil springs on 17×25 SS archwires. Mini-screws were placed between the upper second premolar and first molar without flap elevation or pilot hole drilling. Parameters including screw stability, antimicrobial activity, and gingival blood flow were monitored over a 4-month period. The incorporation of Sr-HA is hypothesized to enhance mini-screw osseointegration, reduce peri-implant inflammation, and improve clinical outcomes by leveraging the osteogenic and antibacterial properties of strontium. This study aims to provide evidence supporting the use of Sr-HA coatings to reduce mini-screw failure rates in orthodontic treatment.
CONDITIONS
Official Title
Strontium-Hydroxyapatite Coated Mini-Screws: Antibacterial Effect and Stability
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients aged 16 to 20 years
- Orthodontic treatment plan requiring extraction of upper first premolars
- Fully erupted permanent teeth (excluding third molars)
- No previous orthodontic treatment
- No medical problems that could interfere with treatment
You will not qualify if you...
- Problematic healing conditions such as compromised immune defense, bleeding disorders, poor bone quality, or dry mouth
- Inadequate oral hygiene
- Heavy smoking
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Mansoura university
Al Mansurah, Dakahlia Governorate, Egypt, 35516
Actively Recruiting
Research Team
H
Hind H jasim Al-khazrajy, Bachelors
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here