Actively Recruiting
Structural and Functional Networks in ALS: An Insight Into Pseudobulbar Affect
Led by Aalborg University Hospital · Updated on 2025-01-29
50
Participants Needed
1
Research Sites
135 weeks
Total Duration
On this page
Sponsors
A
Aalborg University Hospital
Lead Sponsor
U
University of Aarhus
Collaborating Sponsor
AI-Summary
What this Trial Is About
The investigators aim to elucidate characteristics of structural and functional brain connectivity in patients with amyotrophic lateral sclerosis (ALS) and pseudobulbar affect (PBA) using diffusion kurtosis imaging (DKI) and magnetoencephalography (MEG).
CONDITIONS
Official Title
Structural and Functional Networks in ALS: An Insight Into Pseudobulbar Affect
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with ALS in the last 6 months according to Gold Coast Criteria
You will not qualify if you...
- Lack of ability to answer survey through own ability or through a surrogate, for example by hand controlled, eye-controlled computer and/or tablet, or through telephone interview.
- Lack of ability to cooperate.
- Pregnancy
- Drug addiction defined as the non-prescribed use of cannabis, opioids, or other narcotics.
- Alcohol addiction defined as over 21 units weekly.
- Lesional neurological diseases, such as stroke, tumor or multiple sclerosis
- Epilepsy
- Neurodegenerative diseases other than ALS
- Severe psychiatric disease such as major depression disorder, bipolar disease or schizophrenia
- Contraindication for MRI and MEG scan according to hospital guidelines
- Severe liver or kidney disease
- Dysregulated heart disease
- Ongoing treatment with any antidepressants or any antipsychotics at recruitment.
- Diagnosed with frontotemporal dementia.
AI-Screening
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Trial Site Locations
Total: 1 location
1
Aalborg University hospital
Aalborg, Northern Jutland, Denmark, 9500
Actively Recruiting
Research Team
C
Christian Holm Steenkjær
CONTACT
B
Blicher
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
3
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