Actively Recruiting
STRucturation of Transcript Analysis of Genes Involved in Hereditary Cancers
Led by University Hospital, Rouen · Updated on 2025-03-14
1000
Participants Needed
2
Research Sites
82 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Molecular diagnosis using high throughput sequencing has become an essential part of oncogenetic care, making it possible to identify people at risk, to guide surveillance, and to direct preventive surgery and treatment. The quality of this 'precision' care depends on the quality of the interpretation of the genomic variants identified. To be usable in oncogenetics, a genomic variant must be correctly interpreted: pathogenic, benign or of uncertain significance (VSI). The impact of these DNA variants (VSI) on RNA is particularly important for interpretation. Today, due to a lack of resources, joint and systematic DNA/RNA analysis is never carried out. This has inevitably meant that a number of situations of interest have been overlooked. It is now important to go a step further and organise a visible and reliable circuit, allowing routine access to these studies for patients.
CONDITIONS
Official Title
STRucturation of Transcript Analysis of Genes Involved in Hereditary Cancers
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Over 18 years of age
- Patients seen in oncogenetic consultations and who have given their informed consent for genetic analysis in the context of a major predisposition to breast, ovarian or digestive cancer
- Person who has read and understood the information note and does not object to taking part in the study
- Membership of a social security scheme
You will not qualify if you...
- Minors
- Persons deprived of their liberty or adults under guardianship or incapable of giving their consent
- Failure to obtain informed consent
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Service Oncogénétique Centre François Baclesse
Caen, France, 14076
Actively Recruiting
2
Clinique de génétique médicale Guy Fontaine de l'hopital de Flandre CHRU de Lille
Lille, France, 59067
Actively Recruiting
Research Team
D
David MALLET, Director
CONTACT
V
Vincent FERRANTI, Arc
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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