Actively Recruiting
Studies of Disorders With Increased Susceptibility to Fungal Infections
Led by National Institute of Allergy and Infectious Diseases (NIAID) · Updated on 2026-05-07
850
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: \- Researchers are interested in studying disorders that make individuals more susceptible to fungal infections, specifically infections with the Candida yeast. These disorders are often related to problems with the immune system and may have genetic factors, which suggests that researchers should study not only the individual with the disorder, but also his or her first- and second-degree relatives (such as parents, siblings, children, and first cousins). To provide material for future research, individuals with immune disorders and their first- and second-degree relatives will be asked to provide blood and other samples for testing and comparison with samples taken from healthy volunteers with no history of immune disorders. Objectives: \- To collect blood and other biological samples to study immune disorders that make individuals more susceptible to fungal infections. Eligibility: * Individuals of any age who have abnormal immune function characterized by recurrent or unusual fungal infections, recurrent or chronic inflammation, or other types of immune dysfunction. * First- or second-degree genetically related family members (limited to mother, father, siblings, grandparents, children, aunts, uncles, and first cousins). * Healthy volunteers at least 18 years of age (for comparison purposes). Design: * Participants will provide blood samples and buccal (cells from the inside of the mouth near the cheek) samples. * Participants with immune disorders will also be asked to provide urine samples, saliva or mucosal samples, or skin tissue biopsies, and may also have imaging studies (such as x-rays) to collect information for research. * Samples may be collected at the National Institutes of Health or at other clinical locations for the samples to the sent to the National Institutes of Health. * No treatment will be provided as part of this protocol.
CONDITIONS
Official Title
Studies of Disorders With Increased Susceptibility to Fungal Infections
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 2 years or older; children 3 years or younger must not have severe infections to be seen at the Clinical Center
- Abnormal immune function with recurrent or unusual fungal infections, chronic inflammation, or lab evidence of immune dysfunction
- Diagnosed with conditions like APECED, CMC, MPO, IPEX, Job's syndrome, CGD, biotinidase deficiency, IKAROS or AIOLOS defects, IRF4 defects, or related conditions
- Have a primary physician outside NIH
- Agree to have blood stored for future research
- Ability to understand and sign informed consent
- Relatives who are mother, father, sibling, child, grandparent, aunt, uncle, or first cousin of a patient participant
- Relatives aged 2 years or older; children 3 years or younger must not have severe infections to be seen at the Clinical Center
- Adult relatives able to provide informed consent
- Healthy volunteers aged 18 to 85 years
- Hemoglobin count greater than 11 g/dL
- Weigh at least 110 pounds
- Able to provide informed consent
- Willing to have blood stored for future research
You will not qualify if you...
- Patients or relatives with acquired immune problems due to HIV, chemotherapy, or malignancy that interfere with study evaluation
- Pregnant females not allowed in procedures that may harm pregnancy or fetus
- Healthy volunteers receiving chemotherapy or with malignancy
- Healthy volunteers who are pregnant
- Healthy volunteers with heart, lung, kidney disease, or bleeding disorders
- Healthy volunteers with HIV or viral hepatitis B or C, or history of viral hepatitis B or C since age 11
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
S
Sergio D Rosenzweig, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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