The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-β1 production and FcRL4 expression.
Katija Jelicic, Raffaello Cimbro, Fatima Nawaz...
https://pubmed.ncbi.nlm.nih.gov/24162774Actively Recruiting
Age: 18Years - 120Years
All Genders
Healthy Volunteers
ID00001281
Studies of the Pathogenesis of HIV Infection in Human Peripheral Blood Cells and/or Body Fluids in People Living With and Without HIV
Led by National Institute of Allergy and Infectious Diseases (NIAID) · Updated on 2026-06-03
2419
Participants Needed
2
Research Sites
N/A
Total Duration
On this page
Sponsors
N
National Institute of Allergy and Infectious Diseases (NIAID)
Lead Sponsor
M
Medstar Health Research Institute
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating the virologic and immunologic aspects of HIV infection, as well as other infectious and non-infectious immune deficiency diseases, to better understand the disease process of HIV. Due to the lack of suitable animal models, this research uses human peripheral blood cells to study HIV infection both inside the body and in laboratory settings. The goal is to clarify how HIV interacts with immune regulation and dysregulation using human peripheral blood mononuclear cells as a model. This observational study involves groups of people living with or without HIV, those with or without infectious diseases of interest, and individuals with or without immunodeficiencies. The study collects blood products and other biological samples to support various research projects conducted by NIH investigators. These samples will be used throughout the study to analyze HIV and immune-related parameters. Participants provide blood samples and undergo health assessments including blood pressure, pulse, and blood counts. They agree to blood being used for current and future research on HIV infection and pathogenesis, including hepatitis screening. The study measures genomic and proteomic properties of samples from individuals with HIV, infectious diseases, and immunodeficiencies, compared to healthy volunteers. Participation involves ongoing sample collection and monitoring by the NIH research team.
CONDITIONS
Brief Title
Studies of the Pathogenesis of HIV Infection in Human Peripheral Blood Cells and/or Body Fluids in People Living With and Without HIV
Who Can Participate
Age: 18Years - 120Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- 18 years of age or older
- Adequate venous access
- Blood pressure less than or equal to 180/100 and pulse rate between 50 and 100 (or lower pulse rate if normal for the volunteer)
- Adequate blood counts: hemoglobin ≥ 9.0 g/dL and platelets ≥ 50,000
- Willing and able to provide written informed consent and comply with study procedures
- Willing to allow blood samples to be used for future HIV studies and undergo hepatitis screening
You will not qualify if you...
- Pregnant or breastfeeding females
- Active substance abuse or history of substance abuse that may interfere with study compliance or safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Sample Collection
Duration - Throughout the study period
Participants provide blood products and other biologic samples for studies on HIV and other infectious or immune deficiency diseases.
Visits occur as needed for sample collection
Trial Site Locations
Total: 2 locations
1
Washington Hospital Center
Washington D.C., District of Columbia, United States, 20010
Completed
2
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Loading map...
Research Team
C
Catherine A Seamon, R.N.
S
Susan L Moir, Ph.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here
Published Research Related To This Trial
Chronic exposure to type-I IFN under lymphopenic conditions alters CD4 T cell homeostasis.
Cecile Le Saout, Rebecca B Hasley, Hiromi Imamichi...
https://pubmed.ncbi.nlm.nih.gov/24603698Identification of the platelet-derived chemokine CXCL4/PF-4 as a broad-spectrum HIV-1 inhibitor.
David J Auerbach, Yin Lin, Huiyi Miao...
https://pubmed.ncbi.nlm.nih.gov/22645343