What is this study trying to find out about HIV infection?

This study aims to understand the virologic and immunologic aspects of HIV infection and related immune deficiency diseases. Researchers are collecting blood and biological samples to explore how HIV affects the immune system. The research is sponsored by the National Institute of Allergy and Infectious Diseases (NIAID) to help improve knowledge about HIV pathogenesis.

Who may be eligible for this HIV clinical trial?

Adults aged 18 to 120 years who can provide informed consent and have adequate venous access may be eligible. Participants must have acceptable blood pressure and pulse rates and be willing to have blood samples used for HIV research. People who are pregnant, breastfeeding, or have active substance abuse issues may not qualify. Please review eligibility criteria for more details.

Is there any cost to participate in this HIV clinical trial?

Study-related care, including all procedures and sample collection, is provided at no cost. However, personal travel expenses to attend study visits may vary and are not guaranteed to be covered by the study.

Actively Recruiting

Age: 18Years - 120Years

All Genders

Healthy Volunteers

ID00001281

Studies of the Pathogenesis of HIV Infection in Human Peripheral Blood Cells andor Body Fluids in People Living With and Without HIV

Led by National Institute of Allergy and Infectious Diseases (NIAID) · Updated on 2026-06-03

2419

Participants Needed

Research Sites

N/A

Total Duration

AI-Summary

What this Trial Is About

Researchers are investigating the virologic and immunologic aspects of HIV infection, as well as other infectious and non-infectious immune deficiency diseases, to better understand the disease process of HIV. Due to the lack of suitable animal models, this research uses human peripheral blood cells to study HIV infection both inside the body and in laboratory settings. The goal is to clarify how HIV interacts with immune regulation and dysregulation using human peripheral blood mononuclear cells as a model. This observational study involves groups of people living with or without HIV, those with or without infectious diseases of interest, and individuals with or without immunodeficiencies. The study collects blood products and other biological samples to support various research projects conducted by NIH investigators. These samples will be used throughout the study to analyze HIV and immune-related parameters. Participants provide blood samples and undergo health assessments including blood pressure, pulse, and blood counts. They agree to blood being used for current and future research on HIV infection and pathogenesis, including hepatitis screening. The study measures genomic and proteomic properties of samples from individuals with HIV, infectious diseases, and immunodeficiencies, compared to healthy volunteers. Participation involves ongoing sample collection and monitoring by the NIH research team.

CONDITIONS

Brief Title

Studies of the Pathogenesis of HIV Infection in Human Peripheral Blood Cells and/or Body Fluids in People Living With and Without HIV

Who Can Participate

Age: 18Years - 120Years

All Genders

Healthy Volunteers

Eligibility Criteria

You may qualify if you...

18 years of age or older
Adequate venous access
Blood pressure less than or equal to 180/100 and pulse rate between 50 and 100 (or lower pulse rate if normal for the volunteer)
Adequate blood counts: hemoglobin ≥ 9.0 g/dL and platelets ≥ 50,000
Willing and able to provide written informed consent and comply with study procedures
Willing to allow blood samples to be used for future HIV studies and undergo hepatitis screening

You will not qualify if you...

Pregnant or breastfeeding females
Active substance abuse or history of substance abuse that may interfere with study compliance or safety

Research Team

Catherine A Seamon, R.N.

Susan L Moir, Ph.D.

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