Actively Recruiting
Multicentre Randomized Trial on Timing and Effect of Contrast Media in Adhesive Small Bowel Obstruction
Led by University of Tartu · Updated on 2025-03-30
120
Participants Needed
1
Research Sites
17 weeks
Total Duration
On this page
Sponsors
U
University of Tartu
Lead Sponsor
N
North Estonia Medical Centre
Collaborating Sponsor
AI-Summary
What this Trial Is About
This trial investigates adhesive small bowel obstruction (SBO) in hospitalized patients. The study aims to evaluate the effect of timing for administering water-soluble contrast media (CM) after nasogastric tube decompression. It compares whether giving CM sooner or later helps resolve SBO without delaying necessary surgery. Patients eligible for conservative treatment are randomly assigned to receive contrast media either 4 hours or 24 hours after nasogastric decompression. X-rays are taken after the contrast media administration to assess the obstruction. If surgery becomes necessary at any point, it will not be delayed. Participants will be monitored during their hospital stay, typically about 5 days, to track SBO resolution. Researchers collect clinical, laboratory, and radiologic data to evaluate outcomes. The study includes safety oversight to ensure timely surgical intervention when needed.
CONDITIONS
Brief Title
Study About Contrast Media
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients 18 years or older
- Diagnosed with adhesive small bowel obstruction by clinical, laboratory, and radiologic evaluation
- No signs of peritonitis or need for emergency surgery
- Signed informed consent
You will not qualify if you...
- Patients younger than 18 years
- Mechanical small bowel obstruction caused by incarcerated hernias
- Mechanical small bowel obstruction caused by carcinomatosis
- Paralytic small bowel obstruction
- Surgery within the last 6 weeks
- Patients who do not want to be enrolled in the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Approximately 5 days (period of hospitalization)
Participants will receive contrast media either after 4 hours or after 24 hours of nasogastric decompression as part of their management for adhesive small bowel obstruction. Surgery will be performed immediately if needed and will not be delayed.
Daily visits during hospitalization
Trial Site Locations
Total: 1 location
1
Tartu University Hospital
Tartu, Tartu, Estonia, 50406
Actively Recruiting
Research Team
L
Liis Jaanimäe, MD
C
Ceith Nikkolo, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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