Study of Blood Cell Growth Patterns and Heart Health in Children and Young Adults Treated for Classical Hodgkin Lymphoma

What this Trial Is About

Researchers are studying how blood cell growth patterns called therapy-related clonal hematopoiesis t-CH relate to heart health and cardiovascular disease CVD in patients who had Hodgkin lymphoma as children or young adults. The study aims to find out how common t-CH with mutations linked to CVD is in patients treated with certain chemotherapy drugs anthracyclines and to compare heart health between those with and without these blood cell changes using cardiac MRI. They also want to see if factors like radiation, age, sex, or other treatments affect the presence of t-CH and heart disease signs. This is an observational study where participants provide blood samples, complete surveys, and have cardiac MRI scans. Researchers also review medical records and may collect archived blood samples if available. The study focuses on patients who were treated for classical Hodgkin lymphoma with anthracyclines and finished treatment at least two years before joining the study. Participants will be involved in blood collection, surveys, MRI scans, and medical record reviews to assess heart health and blood cell growth patterns. Researchers will measure the presence and expansion of t-CH mutations related to cardiovascular disease over up to one year. The study helps identify who may be at risk for heart problems after cancer treatment so doctors can monitor them more closely. The study is set to complete by October 2028.

A Study About How Blood Cell Growth Patterns Relate to Heart Health After Treatment for Hodgkin Lymphoma