Actively Recruiting
A Study About How Blood Cell Growth Patterns Relate to Heart Health After Treatment for Hodgkin Lymphoma
Led by Children's Oncology Group · Updated on 2026-05-05
190
Participants Needed
32
Research Sites
267 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study assesses how blood cell growth patterns (clonal hematopoiesis) relate to heart health or cardiovascular disease (CVD) after treatment in patients with Hodgkin lymphoma. In some patients, cancer treatment at a young age may lead to later complications, including problems with heart health. Checking for blood cell growth patterns called therapy-related clonal hematopoiesis (t-CH) can help predict who might be at risk for heart health problems after Hodgkin lymphoma treatment. If doctors know who may be at greater risk for developing later heart complications, then they can more closely monitor those patients to prevent or detect heart complications early.
CONDITIONS
Official Title
A Study About How Blood Cell Growth Patterns Relate to Heart Health After Treatment for Hodgkin Lymphoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient must be �3E= 7 years of age at the time of enrollment (age to perform an MRI without sedation).
- History of pathologically confirmed classical Hodgkin Lymphoma (cHL) initially diagnosed when the patient was �3E= 2 and �3C 22 years of age.
- As part of frontline therapy for cHL, the patient must have received a cumulative doxorubicin equivalent anthracycline dose of �3E= 200 mg/m^2 as estimated in doxorubicin isotoxic equivalents dose conversion calculation.
- All systemic cancer treatment must have been completed �3E= 2 years prior to study enrollment.
- Not known to have had a primary event (relapse/second malignancy/death).
- Patient must have access to cardiac MRI at the enrolling institution and must be able to complete cardiac MRI without sedation.
You will not qualify if you...
- Medical contraindication to undergoing a non-contrast cardiac MRI.
- Patients with nodular lymphocyte-predominant HL.
- Received cancer therapy in addition to that for primary Hodgkin Disease (e.g., for disease progression or recurrence, or subsequent malignant neoplasm).
- History of CTCAE grade 3 or higher cardiovascular disease or condition known to exist prior to the patient's initial diagnosis of cHL.
- History of an immunodeficiency that existed prior to cHL diagnosis, such as primary immunodeficiency syndromes, organ transplant recipients and conditions requiring systemic immunosuppressive agents.
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Trial Site Locations
Total: 32 locations
1
USA Health Strada Patient Care Center
Mobile, Alabama, United States, 36604
Actively Recruiting
2
Phoenix Childrens Hospital
Phoenix, Arizona, United States, 85016
Actively Recruiting
3
City of Hope Comprehensive Cancer Center
Duarte, California, United States, 91010
Actively Recruiting
4
Connecticut Children's Medical Center
Hartford, Connecticut, United States, 06106
Actively Recruiting
5
Yale University
New Haven, Connecticut, United States, 06520
Actively Recruiting
6
Alfred I duPont Hospital for Children
Wilmington, Delaware, United States, 19803
Actively Recruiting
7
Golisano Children's Hospital of Southwest Florida
Fort Myers, Florida, United States, 33908
Actively Recruiting
8
Arnold Palmer Hospital for Children
Orlando, Florida, United States, 32806
Actively Recruiting
9
Saint Joseph's Hospital/Children's Hospital-Tampa
Tampa, Florida, United States, 33607
Actively Recruiting
10
Children's Healthcare of Atlanta - Arthur M Blank Hospital
Atlanta, Georgia, United States, 30329
Actively Recruiting
11
Southern Illinois University School of Medicine
Springfield, Illinois, United States, 62702
Actively Recruiting
12
University of Maryland/Greenebaum Cancer Center
Baltimore, Maryland, United States, 21201
Actively Recruiting
13
C S Mott Children's Hospital
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
14
Children's Hospitals and Clinics of Minnesota - Minneapolis
Minneapolis, Minnesota, United States, 55404
Actively Recruiting
15
Washington University School of Medicine
St Louis, Missouri, United States, 63110
Actively Recruiting
16
Hackensack University Medical Center
Hackensack, New Jersey, United States, 07601
Actively Recruiting
17
Albany Medical Center
Albany, New York, United States, 12208
Actively Recruiting
18
Roswell Park Cancer Institute
Buffalo, New York, United States, 14263
Actively Recruiting
19
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States, 27157
Actively Recruiting
20
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States, 45229
Actively Recruiting
21
Nationwide Children's Hospital
Columbus, Ohio, United States, 43205
Actively Recruiting
22
Oregon Health and Science University
Portland, Oregon, United States, 97239
Actively Recruiting
23
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
24
Children's Hospital of Pittsburgh of UPMC
Pittsburgh, Pennsylvania, United States, 15224
Actively Recruiting
25
East Tennessee Childrens Hospital
Knoxville, Tennessee, United States, 37916
Actively Recruiting
26
Cook Children's Medical Center
Fort Worth, Texas, United States, 76104
Actively Recruiting
27
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
28
Children's Hospital of San Antonio
San Antonio, Texas, United States, 78207
Actively Recruiting
29
University of Virginia Cancer Center
Charlottesville, Virginia, United States, 22908
Actively Recruiting
30
Seattle Children's Hospital
Seattle, Washington, United States, 98105
Actively Recruiting
31
University of Wisconsin Carbone Cancer Center - University Hospital
Madison, Wisconsin, United States, 53792
Actively Recruiting
32
Hospital for Sick Children
Toronto, Ontario, Canada, M5G 1X8
Suspended
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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