Actively Recruiting
A Study of Adalimumab in Acute Vogt-Koyanagi-Harada Disease
Led by Tianjin Medical University · Updated on 2024-07-03
15
Participants Needed
1
Research Sites
186 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This project is designed to test the hypothesis that adalimumab is clinically useful for patients with acuta Vogt-Koyanagi-Harada disease
CONDITIONS
Official Title
A Study of Adalimumab in Acute Vogt-Koyanagi-Harada Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 70 years
- No previous, active, or latent tuberculosis (TB)
- Vogt-Koyanagi-Harada disease diagnosed less than one month ago
- Previous systemic glucocorticoid treatment less than one week
- Meets at least one of the following: rejects systemic glucocorticoids due to side effects; has other high-risk or systemic diseases limiting glucocorticoid use; shows little improvement of retinal detachments after one week of strong systemic glucocorticoid treatment (≥1 mg/kg/day)
You will not qualify if you...
- Confirmed or suspected infectious uveitis, including TB, cytomegalovirus, HTLV-1, Whipple's disease, Herpes Zoster virus, Lyme disease, toxoplasmosis, or herpes simplex virus
- Corneal or lens opacity preventing fundus visualization or likely requiring cataract surgery during the study
- Previous exposure to anti-TNF therapy or biologic therapy affecting non-infectious uveitis
- Received Ozurdex (dexamethasone implant) within 6 months before baseline
- Received intravitreal anti-VEGF therapy within 45 days (Lucentis or Avastin) or 60 days (aflibercept) before baseline
- Received intravitreal methotrexate within 90 days before baseline
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Tianjin Medical University Eye Hospital
Tianjin, Tianjin Municipality, China, 300000
Actively Recruiting
Research Team
X
xiaomin zhang, M.D
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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