Actively Recruiting
Study of Added Value of Transmural Evaluation with MRI in Crohns Disease Patients Undergoing Biotherapy with Close Fecal Calprotectin Monitoring
Led by University Hospital, Clermont-Ferrand · Updated on 2022-04-26
180
Participants Needed
17
Research Sites
21 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Crohns disease CD is a chronic inflammatory bowel disease that affects the entire thickness of the intestinal wall, often leading to intestinal damage like stenosis or fistulas and sometimes requiring surgery. This trial aims to compare two treatment strategies for patients with CD who are starting biotherapy, focusing on improving long-term outcomes by combining clinical remission and healing seen with endoscopy and MRI. The study builds upon previous findings that close monitoring with fecal calprotectin and clinical evaluation can improve healing rates.
CONDITIONS
Brief Title
STUDY OF THE ADDED VALUE OF A TRANSMURAL EVALUATION IN PATIENTS WITH CROHN'S DISEASE UNDER BIOTHERAPY WITH CLOSE FECAL CALPROTECTIN FOLLOW-UP
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult Crohn's disease patients aged 18 years or older
- Symptomatic with Crohn's Disease Activity Index (CDAI) greater than 150
- Presence of objective signs of inflammatory activity (fecal calprotectin above 250 and signs of MRI activity)
- Requiring treatment with biotherapy as determined by the investigator
- Able to give informed consent to participate in research
- Affiliated with a Social Security scheme
You will not qualify if you...
- Severe obstructive symptoms
- Uncontrolled intra-abdominal abscess
- Isolated anoperineal lesions
- Prevention of postoperative endoscopic recurrence
- Temporary or permanent ostomy
- Total colectomy
- Contraindication to MRI
- Pregnant or breastfeeding women
- Adults under legal protection (curatorship, guardianship, saving justice)
- Refusal to participate
Research Team
L
Lise Laclautre
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here