Actively Recruiting
Our Study Aims to Determine if Nerve Alterations in Acute GBS and CIDP Detectable by Ultrasound Match Electrodiagnostic Findings and if This Method Aids Early Diagnosis, Predict Their Outcomes and Differentiate Between Axonal and Demyelinating Subtypes.
Led by Assiut University · Updated on 2025-10-03
90
Participants Needed
1
Research Sites
186 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Neuromuscular ultrasound (NMUS) is emerging as a valuable non-invasive diagnostic tool. In GBS, NMUS can detect proximal nerve enlargement early, before neurophysiological changes. Persistent nerve enlargement can be observed up to 15 years, though its correlation with disability varies. Research is needed to clarify NMUS findings in GBS and CIDP over time. Early detection of nerve root enlargement via NMUS could facilitate earlier diagnosis and intervention, improving patient outcomes and understanding of these conditions\' pathophysiology. This study aims to determine if nerve alterations in acute GBS and CIDP detectable by ultrasound match electrodiagnostic findings and if this method aids early diagnosis. The investigators will perform serial nerve ultrasounds and NCS to investigate nerve morphology, predict outcomes, and differentiate between axonal and demyelinating subtypes.
CONDITIONS
Official Title
Our Study Aims to Determine if Nerve Alterations in Acute GBS and CIDP Detectable by Ultrasound Match Electrodiagnostic Findings and if This Method Aids Early Diagnosis, Predict Their Outcomes and Differentiate Between Axonal and Demyelinating Subtypes.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of Guillain Barré Syndrome by NINDS and Brighton Collaboration criteria or CIDP by EFNS/PNS criteria
- Age between 18 and 75 years
- Recent symptom onset within 2 weeks for GBS patients
- Relapsing or progressive course consistent with CIDP diagnosis
- Both male and female participants
- Willingness to participate in study assessments
- Ability to provide informed consent
You will not qualify if you...
- Unable or unwilling to provide informed consent
- Presence of metabolic disorders or malignancies
- Other causes of peripheral neuropathy
- Other causes of acute flaccid paralysis
AI-Screening
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Trial Site Locations
Total: 1 location
1
Assiut University Hospitals
Asyut, Egypt
Actively Recruiting
Research Team
M
Mohammed Gad Ibrahim, MB, BCh
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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